Journal Article

PreJuSER-1104

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Comparative Analysis of Sensory Rhodopsin II Structures in Complex with a Transducer and without It

Reshetnyak, A. B.FZJ* ; Borshchevskii, V. I.FZJ* ; Klare, J. ; Moiseeva, E. S.FZJ* ; Engelhardt, M. ; Büldt, G.FZJ* ; Gordeliy, V. I.FZJ*

2008
MAIK Nauka/Interperiodics Publ. Moscow

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Please use a persistent id in citations: doi:10.1134/S1027451008060128

Abstract: Sensory rhodopsin II (NpSRII) is a heptahelical transmembrane protein containing the retinal chromophore. In complex with another membrane protein, i.e., NpHtrII transducer, NpSRII transmits a signal into a cell, initiating negative phototaxis of Natronobacterium pharaonis. In the absence of a transducer, rhodopsin II can work as a proton pump similar to bacteriorhodopsin. The main objective of this study is to comparatively analyze receptor structures in complex with the transducer and without it to understand the mechanism of the protein switching function. Diffraction data for sensory rhodopsin II crystals grown in the lipidic cubic phase were obtained at the synchrotron x-ray source. In this paper, we present a new NpSRII structure with a resolution of 2.1 angstrom and the results of a comparative analysis of the obtained NpSRII structure with our previously published data on the NpSRII/NpHtrII complex structure and with two NpSRII structures without a transducer, previously published in the literature.

Keyword(s): J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Molekulare Biophysik (INB-2)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2008

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Database coverage:
Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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