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@ARTICLE{Becker:112055,
      author       = {Becker, J.S. and Becker, J.Su.},
      title        = {{M}ass spectrometry imaging ({MSI}) of metals by laser
                      ablation {ICP}-{MS} and metallomics of biomedical samples},
      journal      = {Biomedical Spectroscopy and Imaging},
      volume       = {1},
      number       = {3},
      issn         = {2212-8794},
      address      = {Birmingham, Ala.},
      publisher    = {IOS Press},
      reportid     = {PreJuSER-112055},
      pages        = {187 - 204},
      year         = {2012},
      note         = {Record converted from VDB: 16.11.2012},
      abstract     = {Trace metals are essential in life science and play a major
                      role in biological processes. Knowledge of spatial
                      distribution of metals and metal-containing proteins is
                      fundamental for understanding the pathophysiology of
                      metalloproteins, the impact of metal metabolism and
                      metal-containing deposits in healthy brains and brains of
                      patients suffering from neurological diseases. In recent
                      years, there has been a growing interest in studying metal
                      imaging in biological and especially in clinical tissues. In
                      most neurodegenerative diseases, abnormal metal deposition
                      has been observed within the brain (e.g., in Alzheimer's,
                      Parkinson's or Wilson diseases). Laser-induced mass
                      spectrometry is a novel emerging analytical tool to generate
                      two- and three-dimensional maps of the distribution of
                      elements, isotopes and molecules in different systems. Laser
                      ablation inductively coupled plasma mass spectrometry
                      (LA-ICP-MS) is one of the most important inorganic mass
                      spectrometric technique for solid materials and has been
                      successfully applied to produce quantitative images of
                      detailed regionally specific element distributions in thin
                      soft tissue sections of biological and clinical samples. The
                      spatial resolved “BrainMet” techniques (BrainMet –
                      Bioimaging of Metals in Brain and Metallomics) developed at
                      Research Centre Juelich have been created and established
                      for metal distribution studies in thin biomedical
                      cryosection and it can be employed for fundamental
                      biomedical investigation of biochemical pathways up to
                      single cell level and in future for disease diagnostics and
                      neuroprotective therapies of neurological disorders.},
      cin          = {ZCH},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ZCH-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23043083},
      doi          = {10.3233/BSI-2012-0016},
      url          = {https://juser.fz-juelich.de/record/112055},
}