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000011680 041__ $$aeng
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000011680 084__ $$2WoS$$aBiophysics
000011680 084__ $$2WoS$$aChemistry, Physical
000011680 084__ $$2WoS$$aMaterials Science, Biomaterials
000011680 1001_ $$0P:(DE-HGF)0$$aOszlanczi, A.$$b0
000011680 245__ $$aInfluence of aminoglycoside antibiotics on the thermal behaviour and structural features of DPPE - DPPG model membranes
000011680 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2010
000011680 300__ $$a141 - 148
000011680 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000011680 440_0 $$012541$$aColloids and Surfaces B: Biointerfaces$$v75$$x0927-7765$$y1
000011680 500__ $$aThis work was supported by the Hungarian Scientific Funds OTKA (Bota, T 43055) and a German-Hungarian Research Project. We wish to thank Cs Novak for giving the opportunity for the calorimetric measurements, and Mrs. T. Kiss and Mrs. E Toth for technical assistance at the freeze-fracture and DSC measurements, respectively.
000011680 520__ $$aThe effects of three aminoglycosides (AGs), tobramycin, streptomycin and spectinomycin on 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE)-1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-1-glycerol] (DPPG)/water systems with 0.05 and 0.2 DPPG/DPPE+DPPG molar fractions were examined by using differential scanning calorimetry (DSC), simultaneous small- and wide-angle X-ray scattering (SWAXS), and freeze-fracture transmission electronmicroscopy (FF-TE) at 10(-1) AG/lipid molar ratio in the doped systems. The effects induced by the AGs strongly depend on DPPG/DPPE+DPPG molar fraction. In the presence of the AGs regular lyotropic structures form as opposed to the complex and badly correlated layer structures of the pure 0.2 DPPG/DPPE+DPPG molar fraction system. The investigated AGs possess different structural and thermotropic effects: tobramycin and streptomycin which are true aminoglycosides decrease the main transition enthalpy in both model systems and induce the formation of correlated layer arrangements, while the occurrence of spectinomycin, a non-aminoglycoside aminocyclitol still ranked as an AG, results in a hexagonal phase as it can be deduced from the SAXS patterns and visually observed in the electronmicrographs.
000011680 536__ $$0G:(DE-Juel1)FUEK407$$2G:(DE-HGF)$$aTerrestrische Umwelt$$cP24$$x0
000011680 588__ $$aDataset connected to Web of Science, Pubmed
000011680 65320 $$2Author$$aAminoglycosides
000011680 65320 $$2Author$$aDPPE-DPPG liposomes
000011680 65320 $$2Author$$aDSC
000011680 65320 $$2Author$$aSmall- and wide-angle X-ray scattering (SWAXS)
000011680 65320 $$2Author$$aFreeze-fracture
000011680 650_2 $$2MeSH$$aAminoglycosides: chemistry
000011680 650_2 $$2MeSH$$aAminoglycosides: pharmacology
000011680 650_2 $$2MeSH$$aAnti-Bacterial Agents: chemistry
000011680 650_2 $$2MeSH$$aAnti-Bacterial Agents: pharmacology
000011680 650_2 $$2MeSH$$aCalorimetry, Differential Scanning
000011680 650_2 $$2MeSH$$aFreeze Fracturing
000011680 650_2 $$2MeSH$$aMembranes, Artificial
000011680 650_2 $$2MeSH$$aMicroscopy, Electron, Transmission
000011680 650_2 $$2MeSH$$aModels, Chemical
000011680 650_2 $$2MeSH$$aPhase Transition: drug effects
000011680 650_2 $$2MeSH$$aPhosphatidylethanolamines: chemistry
000011680 650_2 $$2MeSH$$aPhosphatidylglycerols: chemistry
000011680 650_2 $$2MeSH$$aScattering, Small Angle
000011680 650_2 $$2MeSH$$aSpectinomycin: chemistry
000011680 650_2 $$2MeSH$$aSpectinomycin: pharmacology
000011680 650_2 $$2MeSH$$aSurface Properties: drug effects
000011680 650_2 $$2MeSH$$aTemperature
000011680 650_2 $$2MeSH$$aX-Ray Diffraction
000011680 650_7 $$00$$2NLM Chemicals$$aAminoglycosides
000011680 650_7 $$00$$2NLM Chemicals$$aAnti-Bacterial Agents
000011680 650_7 $$00$$2NLM Chemicals$$aMembranes, Artificial
000011680 650_7 $$00$$2NLM Chemicals$$aPhosphatidylethanolamines
000011680 650_7 $$00$$2NLM Chemicals$$aPhosphatidylglycerols
000011680 650_7 $$01695-77-8$$2NLM Chemicals$$aSpectinomycin
000011680 650_7 $$03026-45-7$$2NLM Chemicals$$a1,2-dipalmitoyl-3-phosphatidylethanolamine
000011680 650_7 $$04537-77-3$$2NLM Chemicals$$a1,2-dipalmitoylphosphatidylglycerol
000011680 650_7 $$2WoSType$$aJ
000011680 7001_ $$0P:(DE-HGF)0$$aBóta, A.$$b1
000011680 7001_ $$0P:(DE-Juel1)129484$$aKlumpp, E.$$b2$$uFZJ
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