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@ARTICLE{Oszlanczi:11680,
      author       = {Oszlanczi, A. and Bóta, A. and Klumpp, E.},
      title        = {{I}nfluence of aminoglycoside antibiotics on the thermal
                      behaviour and structural features of {DPPE} - {DPPG} model
                      membranes},
      journal      = {Colloids and surfaces / B},
      volume       = {75},
      issn         = {0927-7765},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-11680},
      pages        = {141 - 148},
      year         = {2010},
      note         = {This work was supported by the Hungarian Scientific Funds
                      OTKA (Bota, T 43055) and a German-Hungarian Research
                      Project. We wish to thank Cs Novak for giving the
                      opportunity for the calorimetric measurements, and Mrs. T.
                      Kiss and Mrs. E Toth for technical assistance at the
                      freeze-fracture and DSC measurements, respectively.},
      abstract     = {The effects of three aminoglycosides (AGs), tobramycin,
                      streptomycin and spectinomycin on
                      1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine
                      (DPPE)-1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-1-glycerol]
                      (DPPG)/water systems with 0.05 and 0.2 DPPG/DPPE+DPPG molar
                      fractions were examined by using differential scanning
                      calorimetry (DSC), simultaneous small- and wide-angle X-ray
                      scattering (SWAXS), and freeze-fracture transmission
                      electronmicroscopy (FF-TE) at 10(-1) AG/lipid molar ratio in
                      the doped systems. The effects induced by the AGs strongly
                      depend on DPPG/DPPE+DPPG molar fraction. In the presence of
                      the AGs regular lyotropic structures form as opposed to the
                      complex and badly correlated layer structures of the pure
                      0.2 DPPG/DPPE+DPPG molar fraction system. The investigated
                      AGs possess different structural and thermotropic effects:
                      tobramycin and streptomycin which are true aminoglycosides
                      decrease the main transition enthalpy in both model systems
                      and induce the formation of correlated layer arrangements,
                      while the occurrence of spectinomycin, a non-aminoglycoside
                      aminocyclitol still ranked as an AG, results in a hexagonal
                      phase as it can be deduced from the SAXS patterns and
                      visually observed in the electronmicrographs.},
      keywords     = {Aminoglycosides: chemistry / Aminoglycosides: pharmacology
                      / Anti-Bacterial Agents: chemistry / Anti-Bacterial Agents:
                      pharmacology / Calorimetry, Differential Scanning / Freeze
                      Fracturing / Membranes, Artificial / Microscopy, Electron,
                      Transmission / Models, Chemical / Phase Transition: drug
                      effects / Phosphatidylethanolamines: chemistry /
                      Phosphatidylglycerols: chemistry / Scattering, Small Angle /
                      Spectinomycin: chemistry / Spectinomycin: pharmacology /
                      Surface Properties: drug effects / Temperature / X-Ray
                      Diffraction / Aminoglycosides (NLM Chemicals) /
                      Anti-Bacterial Agents (NLM Chemicals) / Membranes,
                      Artificial (NLM Chemicals) / Phosphatidylethanolamines (NLM
                      Chemicals) / Phosphatidylglycerols (NLM Chemicals) /
                      Spectinomycin (NLM Chemicals) /
                      1,2-dipalmitoyl-3-phosphatidylethanolamine (NLM Chemicals) /
                      1,2-dipalmitoylphosphatidylglycerol (NLM Chemicals) / J
                      (WoSType)},
      cin          = {ICG-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB793},
      pnm          = {Terrestrische Umwelt},
      pid          = {G:(DE-Juel1)FUEK407},
      shelfmark    = {Biophysics / Chemistry, Physical / Materials Science,
                      Biomaterials},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19748239},
      UT           = {WOS:000278695300018},
      doi          = {10.1016/j.colsurfb.2009.08.027},
      url          = {https://juser.fz-juelich.de/record/11680},
}