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| Home > Publications database > Influence of aminoglycoside antibiotics on the thermal behaviour and structural features of DPPE - DPPG model membranes > print |
| 001 | 11680 | ||
| 005 | 20180208203900.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:19748239 |
| 024 | 7 | _ | |2 DOI |a 10.1016/j.colsurfb.2009.08.027 |
| 024 | 7 | _ | |2 WOS |a WOS:000278695300018 |
| 037 | _ | _ | |a PreJuSER-11680 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 540 |
| 084 | _ | _ | |2 WoS |a Biophysics |
| 084 | _ | _ | |2 WoS |a Chemistry, Physical |
| 084 | _ | _ | |2 WoS |a Materials Science, Biomaterials |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Oszlanczi, A. |b 0 |
| 245 | _ | _ | |a Influence of aminoglycoside antibiotics on the thermal behaviour and structural features of DPPE - DPPG model membranes |
| 260 | _ | _ | |a Amsterdam [u.a.] |b Elsevier Science |c 2010 |
| 300 | _ | _ | |a 141 - 148 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |0 12541 |a Colloids and Surfaces B: Biointerfaces |v 75 |x 0927-7765 |y 1 |
| 500 | _ | _ | |a This work was supported by the Hungarian Scientific Funds OTKA (Bota, T 43055) and a German-Hungarian Research Project. We wish to thank Cs Novak for giving the opportunity for the calorimetric measurements, and Mrs. T. Kiss and Mrs. E Toth for technical assistance at the freeze-fracture and DSC measurements, respectively. |
| 520 | _ | _ | |a The effects of three aminoglycosides (AGs), tobramycin, streptomycin and spectinomycin on 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE)-1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-1-glycerol] (DPPG)/water systems with 0.05 and 0.2 DPPG/DPPE+DPPG molar fractions were examined by using differential scanning calorimetry (DSC), simultaneous small- and wide-angle X-ray scattering (SWAXS), and freeze-fracture transmission electronmicroscopy (FF-TE) at 10(-1) AG/lipid molar ratio in the doped systems. The effects induced by the AGs strongly depend on DPPG/DPPE+DPPG molar fraction. In the presence of the AGs regular lyotropic structures form as opposed to the complex and badly correlated layer structures of the pure 0.2 DPPG/DPPE+DPPG molar fraction system. The investigated AGs possess different structural and thermotropic effects: tobramycin and streptomycin which are true aminoglycosides decrease the main transition enthalpy in both model systems and induce the formation of correlated layer arrangements, while the occurrence of spectinomycin, a non-aminoglycoside aminocyclitol still ranked as an AG, results in a hexagonal phase as it can be deduced from the SAXS patterns and visually observed in the electronmicrographs. |
| 536 | _ | _ | |0 G:(DE-Juel1)FUEK407 |2 G:(DE-HGF) |a Terrestrische Umwelt |c P24 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Aminoglycosides: chemistry |
| 650 | _ | 2 | |2 MeSH |a Aminoglycosides: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Anti-Bacterial Agents: chemistry |
| 650 | _ | 2 | |2 MeSH |a Anti-Bacterial Agents: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Calorimetry, Differential Scanning |
| 650 | _ | 2 | |2 MeSH |a Freeze Fracturing |
| 650 | _ | 2 | |2 MeSH |a Membranes, Artificial |
| 650 | _ | 2 | |2 MeSH |a Microscopy, Electron, Transmission |
| 650 | _ | 2 | |2 MeSH |a Models, Chemical |
| 650 | _ | 2 | |2 MeSH |a Phase Transition: drug effects |
| 650 | _ | 2 | |2 MeSH |a Phosphatidylethanolamines: chemistry |
| 650 | _ | 2 | |2 MeSH |a Phosphatidylglycerols: chemistry |
| 650 | _ | 2 | |2 MeSH |a Scattering, Small Angle |
| 650 | _ | 2 | |2 MeSH |a Spectinomycin: chemistry |
| 650 | _ | 2 | |2 MeSH |a Spectinomycin: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Surface Properties: drug effects |
| 650 | _ | 2 | |2 MeSH |a Temperature |
| 650 | _ | 2 | |2 MeSH |a X-Ray Diffraction |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Aminoglycosides |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Anti-Bacterial Agents |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Membranes, Artificial |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Phosphatidylethanolamines |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Phosphatidylglycerols |
| 650 | _ | 7 | |0 1695-77-8 |2 NLM Chemicals |a Spectinomycin |
| 650 | _ | 7 | |0 3026-45-7 |2 NLM Chemicals |a 1,2-dipalmitoyl-3-phosphatidylethanolamine |
| 650 | _ | 7 | |0 4537-77-3 |2 NLM Chemicals |a 1,2-dipalmitoylphosphatidylglycerol |
| 650 | _ | 7 | |2 WoSType |a J |
| 653 | 2 | 0 | |2 Author |a Aminoglycosides |
| 653 | 2 | 0 | |2 Author |a DPPE-DPPG liposomes |
| 653 | 2 | 0 | |2 Author |a DSC |
| 653 | 2 | 0 | |2 Author |a Small- and wide-angle X-ray scattering (SWAXS) |
| 653 | 2 | 0 | |2 Author |a Freeze-fracture |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Bóta, A. |b 1 |
| 700 | 1 | _ | |0 P:(DE-Juel1)129484 |a Klumpp, E. |b 2 |u FZJ |
| 773 | _ | _ | |0 PERI:(DE-600)1500523-9 |a 10.1016/j.colsurfb.2009.08.027 |g Vol. 75, p. 141 - 148 |p 141 - 148 |q 75<141 - 148 |t Colloids and surfaces / B |v 75 |x 0927-7765 |y 2010 |
| 909 | C | O | |o oai:juser.fz-juelich.de:11680 |p VDB |
| 913 | 1 | _ | |0 G:(DE-Juel1)FUEK407 |a DE-HGF |b Erde und Umwelt |k P24 |l Terrestrische Umwelt |v Terrestrische Umwelt |x 0 |
| 914 | 1 | _ | |y 2010 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
| 920 | 1 | _ | |0 I:(DE-Juel1)VDB793 |d 31.10.2010 |g ICG |k ICG-4 |l Agrosphäre |x 1 |
| 970 | _ | _ | |a VDB:(DE-Juel1)122970 |
| 980 | _ | _ | |a VDB |
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| 980 | _ | _ | |a UNRESTRICTED |
| 981 | _ | _ | |a I:(DE-Juel1)IBG-3-20101118 |
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