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000011684 084__ $$2WoS$$aPhysics, Multidisciplinary
000011684 1001_ $$0P:(DE-HGF)0$$aSmith, A.-S.$$b0
000011684 245__ $$aInferring spatial organization of bonds within adhesion clusters by exploiting fluctuations of soft interfaces
000011684 260__ $$aLes Ulis$$bEDP Sciences$$c2010
000011684 300__ $$a28003
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000011684 440_0 $$018761$$aEPL : a Letters Journal Exploring the Frontiers of Physics$$v89$$x0302-072X$$y2
000011684 500__ $$aWe are grateful to S. GONNENWEIN for giving access to her data (figs. 1 and 4). We thank R. Merkel, E. SACKMANN, U. SEIFERT, C. MONZEL and L. LIMOZIN for stimulating discussions and R. Merkel for careful reading of the manuscript. A-SS was funded by DFG-SE 1119/2-1. KS and SFF thank R. MERKEL for support.
000011684 520__ $$aDetecting the organization of bonds within adhesion domains connecting two interacting membranes is, at present, extremely challenging. Herein we present a technique, based on Reflection Interference Contrast Microscopy, which uses spontaneous thermal fluctuations of a soft interface as a tool to identify the organization of specific ligand-receptor bonds. The key is a time-resolved analysis of micro-interferometric data that systematically quantifies fluctuations and enables the detection of their suppression due to the formation of bonds, which, in turn, allows the identification of the bond organization without the use of fluorescent labelling. The identification of a new type of bond organization characterized by sparsely distributed bonds, as well as detection of pinning centres of nanometric size is presented. Copyright (C) EPLA, 2010
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000011684 7001_ $$0P:(DE-Juel1)VDB84049$$aFenz, S.F.$$b1$$uFZJ
000011684 7001_ $$0P:(DE-HGF)0$$aSengupta, K.$$b2
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