TY  - JOUR
AU  - Trapp, M.
AU  - Gutberlet, T.
AU  - Juranyi, F.
AU  - Unruh, T.
AU  - Demé, B.
AU  - Tehei, M.
AU  - Peters, J.
TI  - Hydration dependent studies of highly aligned multilayer lipid membranes by neutron scattering
JO  - The journal of chemical physics
VL  - 133
SN  - 0021-9606
CY  - Melville, NY
PB  - American Institute of Physics
M1  - PreJuSER-11850
SP  - 164505
PY  - 2010
N1  - The authors thank F. Natali and S. Busch for the fruitful discussions. M. Trapp was supported by a Ph.D. scholarship from the French Ministry for Research and Technology. This research project has been supported by the European Commission under the Sixth Framework Program through the Key Action: Strengthening the European Research Area, Research Infrastructures (Contract No. RII3-CT-2003-5059825). We acknowledge the ILL and the FRM II for the allocation of beamtime and the financial support from the Access to Major Research Facilities Program which is a component of the International Science Linkages Program established under the Australian Government's innovation statement, Backing Australia's Ability.
AB  - We investigated molecular motions on a picosecond timescale of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) model membranes as a function of hydration by using elastic and quasielastic neutron scattering. Two different hydrations corresponding to approximately nine and twelve water molecules per lipid were studied, the latter being the fully hydrated state. In our study, we focused on head group motions by using chain deuterated lipids. Information on in-plane and out-of-plane motions could be extracted by using solid supported DMPC multilayers. Our studies confirm and complete former investigations by König et al. [J. Phys. II (France) 2, 1589 (1992)] and Rheinstädter et al. [Phys. Rev. Lett. 101, 248106 (2008)] who described the dynamics of lipid membranes, but did not explore the influence of hydration on the head group dynamics as presented here. From the elastic data, a clear shift of the main phase transition from the P(β) ripple phase to the L(α) liquid phase was observed. Decreasing water content moves the transition temperature to higher temperatures. The quasielastic data permit a closer investigation of the different types of head group motion of the two samples. Two different models are needed to fit the elastic incoherent structure factor and corresponding radii were calculated. The presented data show the strong influence hydration has on the head group mobility of DMPC.
KW  - Dimyristoylphosphatidylcholine: chemistry
KW  - Membranes, Artificial
KW  - Neutron Diffraction
KW  - Phase Transition
KW  - Water: chemistry
KW  - Membranes, Artificial (NLM Chemicals)
KW  - Dimyristoylphosphatidylcholine (NLM Chemicals)
KW  - Water (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21033803
UR  - <Go to ISI:>//WOS:000283753600036
DO  - DOI:10.1063/1.3495973
UR  - https://juser.fz-juelich.de/record/11850
ER  -