%0 Journal Article
%A Kutschera, U.
%A Pieruschka, R.
%A Berry, J.A.
%T Leaf development, gas exchange characteristics, and photorespiratory activity in maize seedlings
%J Photosynthetica
%V 48
%@ 0300-3604
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V
%M PreJuSER-12994
%P 617 - 622
%D 2010
%Z This work was supported by grants from the Alexander von Humboldt Foundation (AvH-fellowships 2007/2008, Stanford/USA to U. K.). R. P. (Present address: ICG-3: Phytosphere Forschungszentrum Julich, 52425 Julich, Germany) was supported by the Marie Curie International Outgoing Fellowship Program (Nr: 041060 - LIFT).
%X Apoptotic cells were quantitated by light microscopy in a series of 288 breast carcinomas, and their number (cells/mm2 of neoplastic epithelium, i.e., the apoptotic index, AI) was related to various histopathological features and disease outcome. High AI was associated with tumour necrosis (P = 0.003), lack of tubule formation (P = 0.03), dense stromal lymphocyte infiltration (P = 0.0009), high grade of the tumour (P < 0.0001), DNA aneuploidy (P = 0.049), high S-phase fraction (P = 0.010), high mitotic rate (P < 0.0001), lack of sex steroid receptors (P = 0.004), expression of p53 tumour suppressor gene (P = 0.004), and high values of morphometrically measured nuclear factors (P < 0.05). In survival analysis, an AI greater than 3/mm2 was related to short recurrence-free survival in the entire cohort (P = 0.0079) as well as in the axillary lymph node-negative tumours (P = 0.0253). Survival of the patients with node-negative tumours (P = 0.0356), node-positive tumours (P = 0.0085) and in the entire cohort (P = 0.004) was related to AI. Recurrence-free survival was related to the mitotic index (P = 0.0012), ductal type (P = 0.011), S.D. of the nuclear area (P = 0.075), and axillary lymph node status (P = 0.096). Cox's analysis showed that only the tumour diameter (P < 0.001), axillary lymph node status (P = 0.001), progesterone receptor content (P = 0.004) and ductal type (P = 0.041) had independent prognostic value, whereas AI did not.
%K Adult
%K Aged
%K Aged, 80 and over
%K Apoptosis
%K Breast Neoplasms: chemistry
%K Breast Neoplasms: mortality
%K Breast Neoplasms: pathology
%K Carcinoma, Ductal, Breast: pathology
%K Female
%K Flow Cytometry
%K Humans
%K Lymphatic Metastasis
%K Middle Aged
%K Mitotic Index
%K Prognosis
%K Receptors, Progesterone: analysis
%K Survival Rate
%K Receptors, Progesterone (NLM Chemicals)
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:7857705
%U <Go to ISI:>//WOS:000286115100016
%R 10.1007/s11099-010-0079-3
%U https://juser.fz-juelich.de/record/12994