Journal Article

PreJuSER-12994

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Leaf development, gas exchange characteristics, and photorespiratory activity in maize seedlings

Kutschera, U. ; Pieruschka, R.FZJ* ; Berry, J. A.

2010
Springer Science + Business Media B.V Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s11099-010-0079-3

Abstract: Apoptotic cells were quantitated by light microscopy in a series of 288 breast carcinomas, and their number (cells/mm2 of neoplastic epithelium, i.e., the apoptotic index, AI) was related to various histopathological features and disease outcome. High AI was associated with tumour necrosis (P = 0.003), lack of tubule formation (P = 0.03), dense stromal lymphocyte infiltration (P = 0.0009), high grade of the tumour (P < 0.0001), DNA aneuploidy (P = 0.049), high S-phase fraction (P = 0.010), high mitotic rate (P < 0.0001), lack of sex steroid receptors (P = 0.004), expression of p53 tumour suppressor gene (P = 0.004), and high values of morphometrically measured nuclear factors (P < 0.05). In survival analysis, an AI greater than 3/mm2 was related to short recurrence-free survival in the entire cohort (P = 0.0079) as well as in the axillary lymph node-negative tumours (P = 0.0253). Survival of the patients with node-negative tumours (P = 0.0356), node-positive tumours (P = 0.0085) and in the entire cohort (P = 0.004) was related to AI. Recurrence-free survival was related to the mitotic index (P = 0.0012), ductal type (P = 0.011), S.D. of the nuclear area (P = 0.075), and axillary lymph node status (P = 0.096). Cox's analysis showed that only the tumour diameter (P < 0.001), axillary lymph node status (P = 0.001), progesterone receptor content (P = 0.004) and ductal type (P = 0.041) had independent prognostic value, whereas AI did not.

Keyword(s): Adult (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Apoptosis (MeSH) ; Breast Neoplasms: chemistry (MeSH) ; Breast Neoplasms: mortality (MeSH) ; Breast Neoplasms: pathology (MeSH) ; Carcinoma, Ductal, Breast: pathology (MeSH) ; Female (MeSH) ; Flow Cytometry (MeSH) ; Humans (MeSH) ; Lymphatic Metastasis (MeSH) ; Middle Aged (MeSH) ; Mitotic Index (MeSH) ; Prognosis (MeSH) ; Receptors, Progesterone: analysis (MeSH) ; Survival Rate (MeSH) ; Receptors, Progesterone ; J ; leaf development (auto) ; maize seedlings (auto) ; photorespiration (auto) ; photosynthesis (auto)

Note: This work was supported by grants from the Alexander von Humboldt Foundation (AvH-fellowships 2007/2008, Stanford/USA to U. K.). R. P. (Present address: ICG-3: Phytosphere Forschungszentrum Julich, 52425 Julich, Germany) was supported by the Marie Curie International Outgoing Fellowship Program (Nr: 041060 - LIFT).

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Contributing Institute(s):

1. Pflanzenwissenschaften (IBG-2)

Research Program(s):

1. Terrestrische Umwelt (P24)

Appears in the scientific report 2010

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