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@ARTICLE{Kagan:13093,
      author       = {Kagan, V.E. and Konduru, N.V. and Feng, W. and Allen, B.L.
                      and Conroy, J. and Volkov, Y. and Vlasova, I.I. and
                      Belikova, N.A. and Yanamala, N. and Apralov, A and Tyurina,
                      Y.Y. and Kisin, E.R. and Murray, A.R. and Franks, J. and
                      Stolz, D. and Gou, P. and Shi, J. and Klein-Seetharaman, J.
                      and Fadeel, B. and Star, A. and Shvedova, A.},
      title        = {{C}arbon nanotubes degraded by neutrophil myeloperoxidase
                      induce less pulmonary inflammation},
      journal      = {Nature nanotechnology},
      volume       = {5},
      issn         = {1748-3387},
      address      = {London [u.a.]},
      publisher    = {Nature Publishing Group},
      reportid     = {PreJuSER-13093},
      pages        = {354 - 359},
      year         = {2010},
      note         = {This work was supported by grants from National Institute
                      for Occupational Safety and Health (NIOSH) 011008282,
                      National Institutes of Health HL70755, HL094488,
                      U19AI068021, National Library of Medicine LM007994-05,
                      National Occupational Research Agenda (NORA) 927000Y,
                      927Z1LU, Nanotechnology Research Center (NTRC) 927ZJHF,
                      National Science Foundation (NSF) CAREER 0449117, Air Force
                      Office of Scientific Research (AFOSR) FA9550-09-1-0478, 7th
                      Framework Program of the European Commission
                      (EC-FP7-NANOMMUNE-214281) and by the Science Foundation of
                      Ireland, Strategic Research Cluster (SRC) BioNanointeract
                      and Centre for Research on Adaptive Nanostructures and
                      Nanodevices (CRANN), Higher Education Authority (HEA) and
                      Programme for Research in Third-Level Institutions (PRTLI).
                      The authors would like to thank Marcel Bruchez for
                      assistance with dynamic light scattering experiments.},
      abstract     = {We have shown previously that single-walled carbon
                      nanotubes can be catalytically biodegraded over several
                      weeks by the plant-derived enzyme, horseradish peroxidase.
                      However, whether peroxidase intermediates generated inside
                      human cells or biofluids are involved in the biodegradation
                      of carbon nanotubes has not been explored. Here, we show
                      that hypochlorite and reactive radical intermediates of the
                      human neutrophil enzyme myeloperoxidase catalyse the
                      biodegradation of single-walled carbon nanotubes in vitro,
                      in neutrophils and to a lesser degree in macrophages.
                      Molecular modelling suggests that interactions of basic
                      amino acids of the enzyme with the carboxyls on the carbon
                      nanotubes position the nanotubes near the catalytic site.
                      Importantly, the biodegraded nanotubes do not generate an
                      inflammatory response when aspirated into the lungs of mice.
                      Our findings suggest that the extent to which carbon
                      nanotubes are biodegraded may be a major determinant of the
                      scale and severity of the associated inflammatory responses
                      in exposed individuals.},
      keywords     = {Animals / Humans / Immunoglobulin G: immunology / Mice /
                      Mice, Inbred C57BL / Models, Molecular / Nanotubes, Carbon:
                      chemistry / Nanotubes, Carbon: toxicity / Nanotubes, Carbon:
                      ultrastructure / Neutrophils: drug effects / Neutrophils:
                      enzymology / Peroxidase: metabolism / Pneumonia: chemically
                      induced / Pneumonia: pathology / Reactive Oxygen Species:
                      metabolism / Spectrophotometry, Infrared / Spectrum
                      Analysis, Raman / Immunoglobulin G (NLM Chemicals) /
                      Nanotubes, Carbon (NLM Chemicals) / Reactive Oxygen Species
                      (NLM Chemicals) / Peroxidase (NLM Chemicals) / J (WoSType)},
      cin          = {ISB-2},
      ddc          = {600},
      cid          = {I:(DE-Juel1)ISB-2-20090406},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung / NANOMMUNE - Comprehensive
                      assessment of hazardous effects of engineered nanomaterials
                      on the immune system (214281)},
      pid          = {G:(DE-Juel1)FUEK505 / G:(EU-Grant)214281},
      shelfmark    = {Nanoscience $\&$ Nanotechnology / Materials Science,
                      Multidisciplinary},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20364135},
      UT           = {WOS:000278264300015},
      doi          = {10.1038/nnano.2010.44},
      url          = {https://juser.fz-juelich.de/record/13093},
}