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000013117 0247_ $$2DOI$$a10.1002/cmmi.387
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000013117 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000013117 1001_ $$0P:(DE-HGF)0$$aGossuin, Y.$$b0
000013117 245__ $$aNMR relaxation and magnetic properties of superparamagnetic nanoworms
000013117 260__ $$aHoboken, NJ$$bWiley$$c2010
000013117 300__ $$a318 - 322
000013117 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000013117 440_0 $$022341$$aContrast Media & Molecular Imaging$$v5$$x1555-4309$$y6
000013117 500__ $$aThe authors are grateful to Professor Robert N. Muller for helpful discussions. M. J. Sailor is a member of the Moores UCSD Cancer Center and the UCSD NanoTUMOR Center, under which this research was conducted and partially supported by NIH grant U54 CA 119335. Q. L. Vuong acknowledges FNRS for financial support. We acknowledge the European Synchrotron Radiation Facility for provision of synchrotron radiation facilities and we would like to thank Dr Peter Boesecke for assistance in using beamline ID01. We also acknowledge Dr Wim Pyckhout-Hintzen for stimulating discussions.
000013117 520__ $$aMaghemite particles are used as T₂ contrast agents for magnetic resonance imaging, especially for molecular and cellular imaging. Linear clusters of particles - called nanoworms - were recently developed to enhance the targeting efficiency. In this work, the magnetic and NMR relaxation properties of these nanoworms are studied at multiple magnetic fields. After the usual saturation at 0.5 T, the magnetization of the worms is still increasing, which results in an appreciable increase of the transverse relaxivity at high magnetic fields. The obtained relaxivities are typical of superparamagnetic particles of iron oxide (SPIOs). The transverse relaxation of the worms is clearly more efficient than for the isolated grains, which is confirmed by computer simulations. At high field, the longitudinal relaxation of the worms is less pronounced than for the grains, as expected for SPIOs. The nanoworms thus constitute a promising T₂ agent for cellular and molecular imaging.
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000013117 65320 $$2Author$$amagnetic nanoparticles
000013117 65320 $$2Author$$aNMR
000013117 65320 $$2Author$$aMRI contrast agent
000013117 650_2 $$2MeSH$$aContrast Media: chemistry
000013117 650_2 $$2MeSH$$aDextrans
000013117 650_2 $$2MeSH$$aFerric Compounds
000013117 650_2 $$2MeSH$$aImage Enhancement: methods
000013117 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000013117 650_2 $$2MeSH$$aMagnetic Resonance Spectroscopy
000013117 650_2 $$2MeSH$$aMagnetics
000013117 650_2 $$2MeSH$$aMagnetite Nanoparticles: chemistry
000013117 650_7 $$00$$2NLM Chemicals$$aContrast Media
000013117 650_7 $$00$$2NLM Chemicals$$aFerric Compounds
000013117 650_7 $$00$$2NLM Chemicals$$aMagnetite Nanoparticles
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000013117 7001_ $$0P:(DE-Juel1)VDB73876$$aDisch, S.$$b1$$uFZJ
000013117 7001_ $$0P:(DE-HGF)0$$aVuong, Q. L.$$b2
000013117 7001_ $$0P:(DE-HGF)0$$aGillis, P.$$b3
000013117 7001_ $$0P:(DE-Juel1)130706$$aHermann, R.$$b4$$uFZJ
000013117 7001_ $$0P:(DE-HGF)0$$aPark, J.-H.$$b5
000013117 7001_ $$0P:(DE-HGF)0$$aSailor, M. J.$$b6
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000013117 8567_ $$uhttp://dx.doi.org/10.1002/cmmi.387
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