Journal Article

PreJuSER-13117

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png NMR relaxation and magnetic properties of superparamagnetic nanoworms

Gossuin, Y. ; Disch, S.FZJ* ; Vuong, Q. L. ; Gillis, P. ; Hermann, R.FZJ* ; Park, J.-H. ; Sailor, M. J.

2010
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/cmmi.387

Abstract: Maghemite particles are used as T₂ contrast agents for magnetic resonance imaging, especially for molecular and cellular imaging. Linear clusters of particles - called nanoworms - were recently developed to enhance the targeting efficiency. In this work, the magnetic and NMR relaxation properties of these nanoworms are studied at multiple magnetic fields. After the usual saturation at 0.5 T, the magnetization of the worms is still increasing, which results in an appreciable increase of the transverse relaxivity at high magnetic fields. The obtained relaxivities are typical of superparamagnetic particles of iron oxide (SPIOs). The transverse relaxation of the worms is clearly more efficient than for the isolated grains, which is confirmed by computer simulations. At high field, the longitudinal relaxation of the worms is less pronounced than for the grains, as expected for SPIOs. The nanoworms thus constitute a promising T₂ agent for cellular and molecular imaging.

Keyword(s): Contrast Media: chemistry (MeSH) ; Dextrans (MeSH) ; Ferric Compounds (MeSH) ; Image Enhancement: methods (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Magnetic Resonance Spectroscopy (MeSH) ; Magnetics (MeSH) ; Magnetite Nanoparticles: chemistry (MeSH) ; Contrast Media ; Ferric Compounds ; Magnetite Nanoparticles ; ferric oxide ; Dextrans ; J ; magnetic nanoparticles (auto) ; NMR (auto) ; MRI contrast agent (auto)

Note: The authors are grateful to Professor Robert N. Muller for helpful discussions. M. J. Sailor is a member of the Moores UCSD Cancer Center and the UCSD NanoTUMOR Center, under which this research was conducted and partially supported by NIH grant U54 CA 119335. Q. L. Vuong acknowledges FNRS for financial support. We acknowledge the European Synchrotron Radiation Facility for provision of synchrotron radiation facilities and we would like to thank Dr Peter Boesecke for assistance in using beamline ID01. We also acknowledge Dr Wim Pyckhout-Hintzen for stimulating discussions.

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Contributing Institute(s):

1. Streumethoden (IFF-4)
2. Neutronenstreuung (IFF-5)
3. JCNS (Jülich Centre for Neutron Science JCNS (JCNS) ; JCNS)
4. Jülich-Aachen Research Alliance - Fundamentals of Future Information Technology (JARA-FIT)

Research Program(s):

1. Großgeräte für die Forschung mit Photonen, Neutronen und Ionen (PNI) (P55)
2. BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (P45)

Appears in the scientific report 2010

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