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@ARTICLE{Gossuin:13117,
      author       = {Gossuin, Y. and Disch, S. and Vuong, Q. L. and Gillis, P.
                      and Hermann, R. and Park, J.-H. and Sailor, M. J.},
      title        = {{NMR} relaxation and magnetic properties of
                      superparamagnetic nanoworms},
      journal      = {Contrast media $\&$ molecular imaging},
      volume       = {5},
      issn         = {1555-4309},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {PreJuSER-13117},
      pages        = {318 - 322},
      year         = {2010},
      note         = {The authors are grateful to Professor Robert N. Muller for
                      helpful discussions. M. J. Sailor is a member of the Moores
                      UCSD Cancer Center and the UCSD NanoTUMOR Center, under
                      which this research was conducted and partially supported by
                      NIH grant U54 CA 119335. Q. L. Vuong acknowledges FNRS for
                      financial support. We acknowledge the European Synchrotron
                      Radiation Facility for provision of synchrotron radiation
                      facilities and we would like to thank Dr Peter Boesecke for
                      assistance in using beamline ID01. We also acknowledge Dr
                      Wim Pyckhout-Hintzen for stimulating discussions.},
      abstract     = {Maghemite particles are used as T₂ contrast agents for
                      magnetic resonance imaging, especially for molecular and
                      cellular imaging. Linear clusters of particles - called
                      nanoworms - were recently developed to enhance the targeting
                      efficiency. In this work, the magnetic and NMR relaxation
                      properties of these nanoworms are studied at multiple
                      magnetic fields. After the usual saturation at 0.5 T, the
                      magnetization of the worms is still increasing, which
                      results in an appreciable increase of the transverse
                      relaxivity at high magnetic fields. The obtained
                      relaxivities are typical of superparamagnetic particles of
                      iron oxide (SPIOs). The transverse relaxation of the worms
                      is clearly more efficient than for the isolated grains,
                      which is confirmed by computer simulations. At high field,
                      the longitudinal relaxation of the worms is less pronounced
                      than for the grains, as expected for SPIOs. The nanoworms
                      thus constitute a promising T₂ agent for cellular and
                      molecular imaging.},
      keywords     = {Contrast Media: chemistry / Dextrans / Ferric Compounds /
                      Image Enhancement: methods / Magnetic Resonance Imaging:
                      methods / Magnetic Resonance Spectroscopy / Magnetics /
                      Magnetite Nanoparticles: chemistry / Contrast Media (NLM
                      Chemicals) / Ferric Compounds (NLM Chemicals) / Magnetite
                      Nanoparticles (NLM Chemicals) / ferric oxide (NLM Chemicals)
                      / Dextrans (NLM Chemicals) / J (WoSType)},
      cin          = {IFF-4 / IFF-5 / Jülich Centre for Neutron Science JCNS
                      (JCNS) ; JCNS / JARA-FIT},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB784 / I:(DE-Juel1)VDB785 /
                      I:(DE-Juel1)JCNS-20121112 / $I:(DE-82)080009_20140620$},
      pnm          = {Großgeräte für die Forschung mit Photonen, Neutronen und
                      Ionen (PNI) / BioSoft: Makromolekulare Systeme und
                      biologische Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK415 / G:(DE-Juel1)FUEK505},
      shelfmark    = {Radiology, Nuclear Medicine $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21190269},
      UT           = {WOS:000285979900003},
      doi          = {10.1002/cmmi.387},
      url          = {https://juser.fz-juelich.de/record/13117},
}