TY  - JOUR
AU  - Wang-Dietrich, Lei
AU  - Funke, Aileen
AU  - Kühbach, Katja
AU  - Wang, Kun
AU  - Besmehn, Astrid
AU  - Willbold, Sabine
AU  - Cinar, Yeliz
AU  - Bannach, Oliver
AU  - Birkmann, Eva
AU  - Willbold, Dieter
TI  - The Amyloid-β Oligomer Count in Cerebrospinal Fluid is a Biomarker for Alzheimer's Disease
JO  - Journal of Alzheimer's disease
VL  - 34
IS  - 4
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - FZJ-2013-02055
SP  - 985-994
PY  - 2013
AB  - Recent studies indicate that small amyloid-β peptide (Aβ) oligomers are the major toxic species responsible for development and progression of Alzheimer's disease (AD). Therefore, we suggest that the number of Aβ oligomers in body fluids is the most direct and relevant biomarker for AD. Determination of the Aβ oligomer content of cerebrospinal fluid (CSF) samples from 14 AD patients and 12 age-matched controls revealed a clear distinction between both groups. All samples of the control group showed homogenously low numbers of Aβ oligomers, while the samples of the AD group exhibited significantly higher levels of Aβ oligomers. The Aβ oligomer numbers correlated with the patients' Mini-Mental State Examination scores. This indicates that the quantity of Aβ oligomers in CSF reflects the severity of the disease and that Aβ oligomers play a crucial role in AD pathology and in turn can be used as a diagnostic biomarker.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000316464700016
C6  - 23313925
DO  - DOI:10.3233/JAD-122047
UR  - https://juser.fz-juelich.de/record/133640
ER  -