Journal Article

FZJ-2013-02055

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Amyloid-β Oligomer Count in Cerebrospinal Fluid is a Biomarker for Alzheimer's Disease

Wang-Dietrich, L.FZJ* ; Funke, A.FZJ* ; Kühbach, K.FZJ* ; Wang, K.FZJ* ; Besmehn, A.ZEA-3*FZJ* ; Willbold, S.ZEA-3*FZJ* ; Cinar, Y.FZJ* ; Bannach, O.FZJ* ; Birkmann, E.FZJ* ; Willbold, D. (Corresponding author)FZJ*

2013
IOS Press Amsterdam

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Please use a persistent id in citations: http://hdl.handle.net/2128/5096  doi:10.3233/JAD-122047

Abstract: Recent studies indicate that small amyloid-β peptide (Aβ) oligomers are the major toxic species responsible for development and progression of Alzheimer's disease (AD). Therefore, we suggest that the number of Aβ oligomers in body fluids is the most direct and relevant biomarker for AD. Determination of the Aβ oligomer content of cerebrospinal fluid (CSF) samples from 14 AD patients and 12 age-matched controls revealed a clear distinction between both groups. All samples of the control group showed homogenously low numbers of Aβ oligomers, while the samples of the AD group exhibited significantly higher levels of Aβ oligomers. The Aβ oligomer numbers correlated with the patients' Mini-Mental State Examination scores. This indicates that the quantity of Aβ oligomers in CSF reflects the severity of the disease and that Aβ oligomers play a crucial role in AD pathology and in turn can be used as a diagnostic biomarker.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)
2. Analytik (ZEA-3)

Research Program(s):

1. 452 - Structural Biology (POF2-452) (POF2-452)
2. 331 - Signalling Pathways and Mechanisms in the Nervous System (POF2-331) (POF2-331)

Appears in the scientific report 2013

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Database coverage:
; ; ; BIOSIS Previews ; Current Contents - Life Sciences ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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