000133852 001__ 133852
000133852 005__ 20210129211543.0
000133852 0247_ $$2doi$$a10.1016/j.neuroimage.2013.03.013
000133852 0247_ $$2ISSN$$a1095-9572
000133852 0247_ $$2ISSN$$a1053-8119
000133852 0247_ $$2WOS$$aWOS:000320073900013
000133852 0247_ $$2Handle$$a2128/5137
000133852 0247_ $$2altmetric$$aaltmetric:1403874
000133852 0247_ $$2pmid$$apmid:23528923
000133852 037__ $$aFZJ-2013-02243
000133852 082__ $$a610
000133852 1001_ $$0P:(DE-Juel1)131882$$aSilchenko, Alexander$$b0$$eCorresponding author
000133852 245__ $$aImpact of acoustic coordinated reset neuromodulation on effective connectivity in a neural network of phantom sound
000133852 260__ $$aOrlando, Fla.$$bAcademic Press$$c2013
000133852 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s133852
000133852 3367_ $$2DataCite$$aOutput Types/Journal article
000133852 3367_ $$00$$2EndNote$$aJournal Article
000133852 3367_ $$2BibTeX$$aARTICLE
000133852 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000133852 3367_ $$2DRIVER$$aarticle
000133852 500__ $$3POF3_Assignment on 2016-02-29
000133852 520__ $$aChronic subjective tinnitus is an auditory phantom phenomenon characterized by abnormal neuronal synchrony in the central auditory system. As recently shown in a proof of concept clinical trial, acoustic coordinated reset (CR) neuromodulation causes a significant relief of tinnitus symptoms combined with a significant decrease of pathological oscillatory activity in a network comprising auditory and non-auditory brain areas. The objective of the present study was to analyze whether CR therapy caused an alteration of the effective connectivity in a tinnitus related network of localized EEG brain sources. To determine which connections matter, in a first step, we considered a larger network of brain sources previously associated with tinnitus. To that network we applied a data-driven approach, combining empirical mode decomposition and partial directed coherence analysis, in patients with bilateral tinnitus before and after 12weeks of CR therapy as well as in healthy controls. To increase the signal-to-noise ratio, we focused on the good responders, classified by a reliable-change-index (RCI). Prior to CR therapy and compared to the healthy controls, the good responders showed a significantly increased connectivity between the left primary cortex auditory cortex and the posterior cingulate cortex in the gamma and delta bands together with a significantly decreased effective connectivity between the right primary auditory cortex and the dorsolateral prefrontal cortex in the alpha band. Intriguingly, after 12weeks of CR therapy most of the pathological interactions were gone, so that the connectivity patterns of good responders and healthy controls became statistically indistinguishable. In addition, we used dynamic causal modeling (DCM) to examine the types of interactions which were altered by CR therapy. Our DCM results show that CR therapy specifically counteracted the imbalance of excitation and inhibition. CR significantly weakened the excitatory connection between posterior cingulate cortex and primary auditory cortex and significantly strengthened inhibitory connections between auditory cortices and the dorsolateral prefrontal cortex. The overall impact of CR therapy on the entire tinnitus-related network showed up as a qualitative transformation of its spectral response, in terms of a drastic change of the shape of its averaged transfer function. Based on our findings we hypothesize that CR therapy restores a silence based cognitive auditory comparator function of the posterior cingulate cortex.
000133852 536__ $$0G:(DE-HGF)POF2-333$$a333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333)$$cPOF2-333$$fPOF II$$x0
000133852 588__ $$aDataset connected to CrossRef, juser.fz-juelich.de
000133852 7001_ $$0P:(DE-Juel1)131860$$aAdamchic, Ilya$$b1$$ufzj
000133852 7001_ $$0P:(DE-Juel1)131869$$aHauptmann, Christian$$b2$$ufzj
000133852 7001_ $$0P:(DE-Juel1)131884$$aTass, Peter A.$$b3$$ufzj
000133852 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2013.03.013$$p133 - 147$$tNeuroImage$$v77
000133852 8564_ $$uhttps://juser.fz-juelich.de/record/133852/files/FZJ-2013-02243.pdf$$yOpenAccess
000133852 8564_ $$uhttps://juser.fz-juelich.de/record/133852/files/FZJ-2013-02243.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
000133852 8564_ $$uhttps://juser.fz-juelich.de/record/133852/files/FZJ-2013-02243.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
000133852 8564_ $$uhttps://juser.fz-juelich.de/record/133852/files/FZJ-2013-02243.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
000133852 909__ $$ooai:juser.fz-juelich.de:133852$$pVDB
000133852 909CO $$ooai:juser.fz-juelich.de:133852$$pdnbdelivery$$pVDB$$pdriver$$popen_access$$popenaire
000133852 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131882$$aForschungszentrum Jülich GmbH$$b0$$kFZJ
000133852 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131860$$aForschungszentrum Jülich GmbH$$b1$$kFZJ
000133852 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131869$$aForschungszentrum Jülich GmbH$$b2$$kFZJ
000133852 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131884$$aForschungszentrum Jülich GmbH$$b3$$kFZJ
000133852 9101_ $$0I:(DE-588b)5008462-8
000133852 9101_ $$kFZJ
000133852 9101_ $$aForschungszentrum Jülich GmbH
000133852 9101_ $$6P:(DE-Juel1)131882
000133852 9101_ $$b0
000133852 9132_ $$0G:(DE-HGF)POF3-579H$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vAddenda$$x0
000133852 9131_ $$0G:(DE-HGF)POF2-333$$1G:(DE-HGF)POF2-330$$2G:(DE-HGF)POF2-300$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lFunktion und Dysfunktion des Nervensystems$$vPathophysiological Mechanisms of Neurological and Psychiatric Diseases$$x0
000133852 9141_ $$y2013
000133852 915__ $$0StatID:(DE-HGF)0010$$2StatID$$aJCR/ISI refereed
000133852 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000133852 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000133852 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000133852 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000133852 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000133852 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000133852 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000133852 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000133852 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000133852 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000133852 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000133852 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
000133852 980__ $$ajournal
000133852 980__ $$aUNRESTRICTED
000133852 980__ $$aFullTexts
000133852 980__ $$aI:(DE-Juel1)INM-7-20090406
000133852 980__ $$aVDB
000133852 9801_ $$aFullTexts