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@ARTICLE{Shehata:134079,
      author       = {Shehata, M. M. and Scholten, B. and Spahn, I. and Coenen,
                      H. H. and Qaim, S. M.},
      title        = {{R}adiochemical separation of {B}r-76,{B}r-77 and
                      {G}a-66,{G}a-67 from irradiated {Z}n{S}e targets using
                      anion-exchange chromatography},
      journal      = {Radiochimica acta},
      volume       = {100},
      number       = {10},
      address      = {München},
      publisher    = {Oldenbourg},
      reportid     = {FZJ-2013-02439},
      pages        = {785 - 792},
      year         = {2012},
      note         = {All authors thank the operators of the COSY and the Baby
                      Cyclotron at Research Centre Julich for performing the
                      irradiations and S. Spellerberg for technical assistance. M.
                      Shehata is grateful to the Accelerators and Ion Sources
                      Department, Nuclear Research Center, Egyptian Atomic Energy
                      Authority, Cairo, Egypt for a scholarship tenable at
                      Julich.},
      abstract     = {The separation of no-carrier-added (n.c.a.) radiobromine
                      and radiogallium from an irradiated ZnSe target was
                      developed using anion-exchange chromatography. The
                      adsorption behaviour of n.c.a. radiobromine, n.c.a.
                      radiogallium, and macro amounts of zinc and selenium towards
                      the anion-exchange resin Dowex 1 x 10, in Cl- and OH- form,
                      was investigated. Radiobromide was strongly adsorbed on the
                      resin at a low KOH concentration, while n.c.a. radiogallium,
                      zinc and selenium were weakly adsorbed. The adsorbed n.c.a.
                      radiobromine was recovered by 0.2 M H2SO4, followed by
                      addition of KOH, evaporation and redissolution of residue.
                      Finally a K* Br solution was obtained containing about 93
                      +/- $3\%$ of the n.c.a. radiobromine loaded onto the column.
                      The chloride strength in the residual solution (containing
                      n.c.a. radiogallium and macro amounts of zinc and selenium)
                      was increased to 4 M and then loaded onto the Dowex 1 x 10
                      column in Cl- form. Radiogallium (n.c.a.) was adsorbed while
                      zinc and selenium were not. About 94 +/- $2\%$ of the n.c.a.
                      radiogallium loaded on the column was then eluted with 0.1 M
                      HCl. Using this method Br-76,Br-77 and Ga-66,Ga-67 could be
                      obtained in high purity. The radionuclidic purity of the
                      Ga-66/Ga-67 theragnostic pair is high enough for use in
                      medicine. In the case of the Br-76/Br-77 pair, however,
                      highly enriched Se-76 and Se-77 would be needed as target
                      materials, in order to achieve the required radionuclidic
                      purity.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89573 - Neuroimaging
                      (POF2-89573)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000316063800007},
      doi          = {10.1524/ract.2012.1946},
      url          = {https://juser.fz-juelich.de/record/134079},
}