Journal Article

FZJ-2013-02439

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Radiochemical separation of Br-76,Br-77 and Ga-66,Ga-67 from irradiated ZnSe targets using anion-exchange chromatography

Shehata, M. M. (Corresponding author) ; Scholten, B.FZJ* ; Spahn, I.FZJ* ; Coenen, H. H.FZJ* ; Qaim, S. M.FZJ*

2012
Oldenbourg München

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Please use a persistent id in citations: http://hdl.handle.net/2128/16374  doi:10.1524/ract.2012.1946

Abstract: The separation of no-carrier-added (n.c.a.) radiobromine and radiogallium from an irradiated ZnSe target was developed using anion-exchange chromatography. The adsorption behaviour of n.c.a. radiobromine, n.c.a. radiogallium, and macro amounts of zinc and selenium towards the anion-exchange resin Dowex 1 x 10, in Cl- and OH- form, was investigated. Radiobromide was strongly adsorbed on the resin at a low KOH concentration, while n.c.a. radiogallium, zinc and selenium were weakly adsorbed. The adsorbed n.c.a. radiobromine was recovered by 0.2 M H2SO4, followed by addition of KOH, evaporation and redissolution of residue. Finally a K* Br solution was obtained containing about 93 +/- 3% of the n.c.a. radiobromine loaded onto the column. The chloride strength in the residual solution (containing n.c.a. radiogallium and macro amounts of zinc and selenium) was increased to 4 M and then loaded onto the Dowex 1 x 10 column in Cl- form. Radiogallium (n.c.a.) was adsorbed while zinc and selenium were not. About 94 +/- 2% of the n.c.a. radiogallium loaded on the column was then eluted with 0.1 M HCl. Using this method Br-76,Br-77 and Ga-66,Ga-67 could be obtained in high purity. The radionuclidic purity of the Ga-66/Ga-67 theragnostic pair is high enough for use in medicine. In the case of the Br-76/Br-77 pair, however, highly enriched Se-76 and Se-77 would be needed as target materials, in order to achieve the required radionuclidic purity.

Note: All authors thank the operators of the COSY and the Baby Cyclotron at Research Centre Julich for performing the irradiations and S. Spellerberg for technical assistance. M. Shehata is grateful to the Accelerators and Ion Sources Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt for a scholarship tenable at Julich.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333) (POF2-333)
2. 89573 - Neuroimaging (POF2-89573) (POF2-89573)

Appears in the scientific report 2012

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Database coverage:
; JCR ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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