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Journal Article FZJ-2013-03862

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Functional characterization and differential co-activation patterns of two cytoarchitectonic visual areas on the human posterior fusiform gyrus

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2014
Wiley-Liss New York, NY

Human brain mapping 35(6), 2754-2767 () [10.1002/hbm.22364]

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Abstract: The ventral stream of the human extrastriate visual cortex shows a considerable functional heterogeneity from early visual processing (posterior) to higher, domain-specific processing (anterior). The fusiform gyrus hosts several of those “high-level” functional areas. We recently found a subdivision of the posterior fusiform gyrus on the microstructural level, that is, two distinct cytoarchitectonic areas, FG1 and FG2 (Caspers et al., Brain Structure & Function, 2013). To gain a first insight in the function of these two areas, here we studied their behavioral involvement and coactivation patterns by means of meta-analytic connectivity modeling based on the BrainMap database (www.brainmap.org), using probabilistic maps of these areas as seed regions. The coactivation patterns of the areas support the concept of a common involvement in a core network subserving different cognitive tasks, that is, object recognition, visual language perception, or visual attention. In addition, the analysis supports the previous cytoarchitectonic parcellation, indicating that FG1 appears as a transitional area between early and higher visual cortex and FG2 as a higher-order one. The latter area is furthermore lateralized, as it shows strong relations to the visual language processing system in the left hemisphere, while its right side is stronger associated with face selective regions. These findings indicate that functional lateralization of area FG2 relies on a different pattern of connectivity rather than side-specific cytoarchitectonic features

Classification:

Contributing Institute(s):
  1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
  2. JARA-BRAIN (JARA-BRAIN)
Research Program(s):
  1. 333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333) (POF2-333)
  2. 89571 - Connectivity and Activity (POF2-89571) (POF2-89571)
  3. HASB - Helmholtz Alliance on Systems Biology (HGF-SystemsBiology) (HGF-SystemsBiology)
  4. HelMA - Helmholtz Alliance for Mental Health in an Ageing Society (HGF-HelMA-2007-2013) (HGF-HelMA-2007-2013)

Appears in the scientific report 2014
Database coverage:
Medline ; BIOSIS Previews ; Current Contents - Life Sciences ; JCR ; NCBI Molecular Biology Database ; NationallizenzNationallizenz ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection
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