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@ARTICLE{SchulteRther:137678,
      author       = {Schulte-Rüther, Martin and Greimel, E. and Piefke, M. and
                      Kamp-Becker, I. and Remschmidt, H. and Fink, Gereon Rudolf
                      and Herpertz-Dahlmann, B. and Konrad, K.},
      title        = {{A}ge dependent changes in the neural substrates of empathy
                      in {A}utism {S}pectrum {D}isorder},
      journal      = {Social cognitive and affective neuroscience},
      volume       = {9},
      number       = {8},
      issn         = {1749-5016},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2013-04024},
      pages        = {1118-1126},
      year         = {2014},
      abstract     = {In typical development, empathic abilities continue to
                      refine during adolescence and early adulthood. Children and
                      adolescents with autism spectrum disorders (ASD) show
                      deficits in empathy, whereas adults with ASD may have
                      developed compensatory strategies. We aimed at comparing
                      developmental trajectories in the neural mechanisms
                      underlying empathy in individuals with ASD and typically
                      developing control (TDC) subjects. Using an explicit
                      empathizing paradigm and functional magnetic resonance
                      imaging, 27 participants with ASD and 27 TDC aged 12–31
                      years were investigated. Participants were asked to
                      empathize with emotional faces and to either infer the
                      face’s emotional state (other-task) or to judge their own
                      emotional response (self-task). Differential age-dependent
                      changes were evident during the self-task in the right
                      dorsolateral prefrontal cortex, right medial prefrontal
                      cortex, right inferior parietal cortex, right anterior
                      insula and occipital cortex. Age-dependent decreases in
                      neural activation in TDC were paralleled by either
                      increasing or unchanged age-dependent activation in ASD.
                      These data suggest ASD-associated deviations in the
                      developmental trajectories of self-related processing during
                      empathizing. In TDC, age-dependent modulations of brain
                      areas may reflect the ‘fine-tuning’ of cortical networks
                      by reduction of task-unspecific brain activity. Increased
                      age-related activation in individuals with ASD may indicate
                      the development of compensatory mechanisms.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000342984900010},
      pubmed       = {pmid:23784073},
      doi          = {10.1093/scan/nst088},
      url          = {https://juser.fz-juelich.de/record/137678},
}