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@ARTICLE{Ramms:138794,
      author       = {Ramms, L. and Fabris, G. and Windoffer, R. and Schwarz, N.
                      and Springer, R. and Zhou, C. and Lazar, J. and Stiefel, S.
                      and Hersch, N. and Schnakenberg, U. and Magin, T. M. and
                      Leube, R. E. and Merkel, R. and Hoffmann, B.},
      title        = {{K}eratins as the main component for the mechanical
                      integrity of keratinocytes},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {110},
      number       = {46},
      issn         = {1091-6490},
      address      = {Washington, DC},
      publisher    = {Academy},
      reportid     = {FZJ-2013-04875},
      pages        = {18513–18518},
      year         = {2013},
      abstract     = {For decades, researchers have been trying to unravel one of
                      the key questions in cell biology regarding keratin
                      intermediate filament function in protecting epithelial
                      cells against mechanical stress. For many different reasons,
                      however, this fundamental hypothesis was still unproven.
                      Here we answer this pivotal question by the use of keratin
                      KO cells lacking complete keratin gene clusters to result in
                      total loss of keratin filaments. This lack significantly
                      softens cells, reduces cell viscosity, and elevates plastic
                      cell deformation on force application. Reexpression of
                      single keratin genes facilitates biomechanical
                      complementation of complete cluster loss. Our manuscript
                      therefore makes a very strong case for the crucial
                      contribution of keratins to cell mechanics, with
                      far-reaching implications for epithelial pathophysiology.},
      cin          = {ICS-7},
      ddc          = {000},
      cid          = {I:(DE-Juel1)ICS-7-20110106},
      pnm          = {453 - Physics of the Cell (POF2-453)},
      pid          = {G:(DE-HGF)POF2-453},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000326830900053},
      pubmed       = {pmid:24167246},
      doi          = {10.1073/pnas.1313491110},
      url          = {https://juser.fz-juelich.de/record/138794},
}