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| 001 | 138794 | ||
| 005 | 20210129212353.0 | ||
| 024 | 7 | _ | |a 10.1073/pnas.1313491110 |2 doi |
| 024 | 7 | _ | |a 1091-6490 |2 ISSN |
| 024 | 7 | _ | |a 0027-8424 |2 ISSN |
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| 037 | _ | _ | |a FZJ-2013-04875 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 000 |
| 100 | 1 | _ | |a Ramms, L. |0 P:(DE-Juel1)151217 |b 0 |u fzj |e Corresponding author |
| 245 | _ | _ | |a Keratins as the main component for the mechanical integrity of keratinocytes |
| 260 | _ | _ | |a Washington, DC |c 2013 |b Academy |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1392904742_25623 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a article |2 DRIVER |
| 500 | _ | _ | |3 POF3_Assignment on 2016-02-29 |
| 520 | _ | _ | |a For decades, researchers have been trying to unravel one of the key questions in cell biology regarding keratin intermediate filament function in protecting epithelial cells against mechanical stress. For many different reasons, however, this fundamental hypothesis was still unproven. Here we answer this pivotal question by the use of keratin KO cells lacking complete keratin gene clusters to result in total loss of keratin filaments. This lack significantly softens cells, reduces cell viscosity, and elevates plastic cell deformation on force application. Reexpression of single keratin genes facilitates biomechanical complementation of complete cluster loss. Our manuscript therefore makes a very strong case for the crucial contribution of keratins to cell mechanics, with far-reaching implications for epithelial pathophysiology. |
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| 700 | 1 | _ | |a Windoffer, R. |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Schwarz, N. |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Springer, R. |0 P:(DE-Juel1)144199 |b 4 |u fzj |
| 700 | 1 | _ | |a Zhou, C. |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Lazar, J. |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Stiefel, S. |0 P:(DE-Juel1)161241 |b 7 |u fzj |
| 700 | 1 | _ | |a Hersch, N. |0 P:(DE-Juel1)128815 |b 8 |u fzj |
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| 773 | _ | _ | |a 10.1073/pnas.1313491110 |g p. 1313491110 |p 18513–18518 |n 46 |0 PERI:(DE-600)1461794-8 |t Proceedings of the National Academy of Sciences of the United States of America |v 110 |x 1091-6490 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/138794/files/FZJ-2013-04875.pdf |z Published final document. |y Restricted |
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