% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Zhang:139442,
      author       = {Zhang, Ke and Langen, Karl-Josef and Neuner, Irene and
                      Stoffels, Gabriele and Filss, Christian and Galldiks,
                      Norbert and Tellmann, Lutz and Rota Kops, Elena and Coenen,
                      Heinrich Hubert and Herzog, Hans and Shah, N. J.},
      title        = {{R}elationship of {R}egional {C}erebral {B}lood {F}low and
                      {K}inetic {B}ehaviour of {O}-(2-18{F}-
                      {F}luoroethyl)-{L}-{T}yrosine {U}ptake in {C}erebral
                      {G}liomas.},
      journal      = {Nuclear medicine communications},
      volume       = {35},
      number       = {3},
      issn         = {1473-5628},
      address      = {London},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {FZJ-2013-05431},
      pages        = {245–251},
      year         = {2014},
      abstract     = {Objectives: O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) is
                      an established tracer for brain tumour imaging. 18F-FET
                      kinetics in gliomas appear to have potential for tumour
                      grading, but the mechanisms remain unclear. The aim of this
                      study was to explore the relationship between regional
                      cerebral blood flow (rCBF) as measured by arterial spin
                      labelling MRI and the kinetic behaviour of 18F-FET PET in
                      cerebral gliomas.Materials and methods: Twenty patients with
                      cerebral gliomas were investigated using arterial spin
                      labelling MRI and dynamic 18F-FET PET. Time–activity
                      curves (TACs) of 18F-FET uptake were analysed in 33
                      different tumour regions. The slopes of TAC during the early
                      (0–5 min; slopeup) and late phases of tracer uptake
                      (17–50 min; slopedown) were fitted using linear regression
                      lines. In addition, TACs of each lesion were assigned to
                      different curve patterns. Furthermore, we calculated
                      tumour-to-brain ratios of 18F-FET uptake. The relationship
                      between 18F-FET parameters and rCBF was determined.Results:
                      18F-FET uptake in the early phase (slopeup) showed a
                      significant correlation with rCBF (r=0.4; P=0.02). In
                      contrast, both slopedown and TAC patterns showed no
                      significant correlation with rCBF. Furthermore, a
                      significant correlation was found between rCBF and
                      tumour-to-brain ratio (r=0.53; P=0.002).Conclusion: There is
                      a relationship between rCBF and 18F-FET uptake in cerebral
                      gliomas in the initial uptake phase, but the kinetic
                      behaviour of 18F-FET uptake in the late phase is not
                      significantly influenced by rCBF. Thus, the differential
                      kinetic pattern of 18F-FET uptake in high-grade and
                      low-grade gliomas appears to be determined by factors other
                      than rCBF},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000331291000004},
      pubmed       = {pmid:24240195},
      doi          = {10.1097/MNM.0000000000000036},
      url          = {https://juser.fz-juelich.de/record/139442},
}