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000014183 0247_ $$2DOI$$a10.1016/j.jcis.2010.10.060
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000014183 084__ $$2WoS$$aChemistry, Physical
000014183 1001_ $$0P:(DE-HGF)0$$aMangiapia, G.$$b0
000014183 245__ $$aNanostructuring of CyPlos (cyclic phosphate-linked oligosaccharides), novel saccharide-based synthetic ion transporters
000014183 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2011
000014183 300__ $$a718 - 724
000014183 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000014183 440_0 $$03193$$aJournal of Colloid and Interface Science$$v354$$x0021-9797$$y2
000014183 500__ $$aSome of the authors wish to thank the Forschungszentrum Julich for having provided neutron beam-time. The research has been supported by MIUR (Ministero dell'Istruzione, dell'Universita e della Ricerca) through the PRIN 2008. Dr. Giuseppe Pesce is fully acknowledged for the provision of microscope images.
000014183 520__ $$aIonophores are an important class of synthetic molecules which mimic natural ion channels or carriers. Here we report the aggregation behavior in pseudo-physiological environment of three Cyclic Phosphate-Linked Oligosaccharides (CyPLOS) derivatives, synthetic ion transporters based on cyclic, phosphate-linked disaccharide skeleton differing for the nature of the tails (tetraethylene-TEG glycol and/or n-undecyl chains) attached to the C-2 and C-3 of the constitutive monosaccharides. Their aggregation behavior has been studied by a combined use of dynamic light scattering (DLS), electron paramagnetic resonance spectroscopy (EPR) and Small Angle Neutron Scattering (SANS). DLS measurements were performed to reveal the formation and size distribution of the CyPLOS aggregates. EPR measurements, by using 5-doxyl stearic acid (5-DSA) as spin-probe, showed that the aggregates are mainly due to the formation of double layers and allowed to analyze the local fluidity. Finally, SANS measurements allowed estimating the layer thickness of the double layers. Our results indicate that the three CyPLOS analogs show self-aggregation properties that depend on the different nature of the inserted tails.
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000014183 65320 $$2Author$$aIonophores
000014183 65320 $$2Author$$aNanostructures
000014183 65320 $$2Author$$aDynamic light scattering (DLS)
000014183 65320 $$2Author$$aElectron paramagnetic resonance spectroscopy (EPR)
000014183 65320 $$2Author$$aSmall Angle Neutron Scattering (SANS)
000014183 650_2 $$2MeSH$$aCyclization
000014183 650_2 $$2MeSH$$aElectron Spin Resonance Spectroscopy
000014183 650_2 $$2MeSH$$aIonophores: chemistry
000014183 650_2 $$2MeSH$$aLight
000014183 650_2 $$2MeSH$$aNanostructures: chemistry
000014183 650_2 $$2MeSH$$aNanostructures: ultrastructure
000014183 650_2 $$2MeSH$$aOligosaccharides: chemistry
000014183 650_2 $$2MeSH$$aPhosphates: chemistry
000014183 650_2 $$2MeSH$$aScattering, Radiation
000014183 650_7 $$00$$2NLM Chemicals$$aIonophores
000014183 650_7 $$00$$2NLM Chemicals$$aOligosaccharides
000014183 650_7 $$00$$2NLM Chemicals$$aPhosphates
000014183 650_7 $$2WoSType$$aJ
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000014183 7001_ $$0P:(DE-HGF)0$$aCoppola, C.$$b1
000014183 7001_ $$0P:(DE-HGF)0$$aVitiello, G.$$b2
000014183 7001_ $$0P:(DE-HGF)0$$ad'Errico, G.$$b3
000014183 7001_ $$0P:(DE-HGF)0$$adeNapoli, L.$$b4
000014183 7001_ $$0P:(DE-Juel1)VDB4342$$aRadulescu, A.$$b5$$uFZJ
000014183 7001_ $$0P:(DE-HGF)0$$aMontesarchio, D.$$b6
000014183 7001_ $$0P:(DE-HGF)0$$aPaduano, L.$$b7
000014183 773__ $$0PERI:(DE-600)1469021-4$$a10.1016/j.jcis.2010.10.060$$gVol. 354, p. 718 - 724$$p718 - 724$$q354<718 - 724$$tJournal of colloid and interface science$$v354$$x0021-9797$$y2011
000014183 8567_ $$uhttp://dx.doi.org/10.1016/j.jcis.2010.10.060
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