Journal Article

PreJuSER-14183

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Nanostructuring of CyPlos (cyclic phosphate-linked oligosaccharides), novel saccharide-based synthetic ion transporters

Mangiapia, G. ; Coppola, C. ; Vitiello, G. ; d'Errico, G. ; deNapoli, L. ; Radulescu, A.FZJ* ; Montesarchio, D. ; Paduano, L.

2011
Elsevier Amsterdam [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1016/j.jcis.2010.10.060

Abstract: Ionophores are an important class of synthetic molecules which mimic natural ion channels or carriers. Here we report the aggregation behavior in pseudo-physiological environment of three Cyclic Phosphate-Linked Oligosaccharides (CyPLOS) derivatives, synthetic ion transporters based on cyclic, phosphate-linked disaccharide skeleton differing for the nature of the tails (tetraethylene-TEG glycol and/or n-undecyl chains) attached to the C-2 and C-3 of the constitutive monosaccharides. Their aggregation behavior has been studied by a combined use of dynamic light scattering (DLS), electron paramagnetic resonance spectroscopy (EPR) and Small Angle Neutron Scattering (SANS). DLS measurements were performed to reveal the formation and size distribution of the CyPLOS aggregates. EPR measurements, by using 5-doxyl stearic acid (5-DSA) as spin-probe, showed that the aggregates are mainly due to the formation of double layers and allowed to analyze the local fluidity. Finally, SANS measurements allowed estimating the layer thickness of the double layers. Our results indicate that the three CyPLOS analogs show self-aggregation properties that depend on the different nature of the inserted tails.

Keyword(s): Cyclization (MeSH) ; Electron Spin Resonance Spectroscopy (MeSH) ; Ionophores: chemistry (MeSH) ; Light (MeSH) ; Nanostructures: chemistry (MeSH) ; Nanostructures: ultrastructure (MeSH) ; Oligosaccharides: chemistry (MeSH) ; Phosphates: chemistry (MeSH) ; Scattering, Radiation (MeSH) ; Ionophores ; Oligosaccharides ; Phosphates ; J ; Ionophores (auto) ; Nanostructures (auto) ; Dynamic light scattering (DLS) (auto) ; Electron paramagnetic resonance spectroscopy (EPR) (auto) ; Small Angle Neutron Scattering (SANS) (auto)

Note: Some of the authors wish to thank the Forschungszentrum Julich for having provided neutron beam-time. The research has been supported by MIUR (Ministero dell'Istruzione, dell'Universita e della Ricerca) through the PRIN 2008. Dr. Giuseppe Pesce is fully acknowledged for the provision of microscope images.

---

Contributing Institute(s):

1. Streumethoden (PGI-4)
2. Neutronenstreuung (ICS-1)
3. JCNS (Jülich Centre for Neutron Science JCNS (JCNS) ; JCNS)

Research Program(s):

1. BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (P45)
2. Großgeräte für die Forschung mit Photonen, Neutronen und Ionen (PNI) (P55)

Experiment(s):

1. KWS-2: Small angle scattering diffractometer (NL3ao)

Appears in the scientific report 2011

---