TY  - JOUR
AU  - Mangiapia, G.
AU  - Coppola, C.
AU  - Vitiello, G.
AU  - d'Errico, G.
AU  - deNapoli, L.
AU  - Radulescu, A.
AU  - Montesarchio, D.
AU  - Paduano, L.
TI  - Nanostructuring of CyPlos (cyclic phosphate-linked oligosaccharides), novel saccharide-based synthetic ion transporters
JO  - Journal of colloid and interface science
VL  - 354
SN  - 0021-9797
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - PreJuSER-14183
SP  - 718 - 724
PY  - 2011
N1  - Some of the authors wish to thank the Forschungszentrum Julich for having provided neutron beam-time. The research has been supported by MIUR (Ministero dell'Istruzione, dell'Universita e della Ricerca) through the PRIN 2008. Dr. Giuseppe Pesce is fully acknowledged for the provision of microscope images.
AB  - Ionophores are an important class of synthetic molecules which mimic natural ion channels or carriers. Here we report the aggregation behavior in pseudo-physiological environment of three Cyclic Phosphate-Linked Oligosaccharides (CyPLOS) derivatives, synthetic ion transporters based on cyclic, phosphate-linked disaccharide skeleton differing for the nature of the tails (tetraethylene-TEG glycol and/or n-undecyl chains) attached to the C-2 and C-3 of the constitutive monosaccharides. Their aggregation behavior has been studied by a combined use of dynamic light scattering (DLS), electron paramagnetic resonance spectroscopy (EPR) and Small Angle Neutron Scattering (SANS). DLS measurements were performed to reveal the formation and size distribution of the CyPLOS aggregates. EPR measurements, by using 5-doxyl stearic acid (5-DSA) as spin-probe, showed that the aggregates are mainly due to the formation of double layers and allowed to analyze the local fluidity. Finally, SANS measurements allowed estimating the layer thickness of the double layers. Our results indicate that the three CyPLOS analogs show self-aggregation properties that depend on the different nature of the inserted tails.
KW  - Cyclization
KW  - Electron Spin Resonance Spectroscopy
KW  - Ionophores: chemistry
KW  - Light
KW  - Nanostructures: chemistry
KW  - Nanostructures: ultrastructure
KW  - Oligosaccharides: chemistry
KW  - Phosphates: chemistry
KW  - Scattering, Radiation
KW  - Ionophores (NLM Chemicals)
KW  - Oligosaccharides (NLM Chemicals)
KW  - Phosphates (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21111429
UR  - <Go to ISI:>//WOS:000286157000039
DO  - DOI:10.1016/j.jcis.2010.10.060
UR  - https://juser.fz-juelich.de/record/14183
ER  -