Home > Publications database > Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation > print

001     14281
005     20200402210002.0
024 7 _ |2 pmid
|a pmid:21147989
024 7 _ |2 pmc
|a pmc:PMC3393111
024 7 _ |2 DOI
|a 10.1523/JNEUROSCI.4225-10.2010
024 7 _ |2 WOS
|a WOS:000285089100011
024 7 _ |a altmetric:4460606
|2 altmetric
037 _ _ |a PreJuSER-14281
041 _ _ |a eng
082 _ _ |a 590
084 _ _ |2 WoS
|a Neurosciences
100 1 _ |0 P:(DE-HGF)0
|a Mobley, A.S.
|b 0
245 _ _ |a Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation
260 _ _ |a Washington, DC
|b Soc.
|c 2010
300 _ _ |a 16498 - 16508
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |0 3603
|a Journal of Neuroscience
|v 30
|x 0270-6474
|y 49
500 _ _ |a This work was funded by National Institutes of Health (NIH)-National Institute on Deafness and Other Communication Disorders and NIH-National Institute on Aging grants (C.A.G.). A.M.M. was supported by Medical Scientist Training Program Grant GM07205 and NIH Grant F30 DC010324. A.S.M. was supported by Neurobiology Training Grant NS 007224-24 and National Research Service Award F32 DC010098-01A1. We thank Drs. L. Rela and M. B. Richard for developing the whole-mount imaging technique in our lab. HCN antibodies were generously provided by Dr. R. Shigemoto, National Institute for Physiological Sciences, Japan.
520 _ _ |a Mechanisms influencing the development of olfactory bulb glomeruli are poorly understood. While odor receptors (ORs) play an important role in olfactory sensory neuron (OSN) axon targeting/coalescence (Mombaerts et al., 1996; Wang et al., 1998; Feinstein and Mombaerts, 2004), recent work showed that G protein activation alone is sufficient to induce OSN axon coalescence (Imai et al., 2006; Chesler et al., 2007), suggesting an activity-dependent mechanism in glomerular development. Consistent with these data, OSN axon projections and convergence are perturbed in mice deficient for adenylyl cyclase III, which is downstream from the OR and catalyzes the conversion of ATP to cAMP. However, in cyclic nucleotide-gated (CNG) channel knock-out mice OSN axons are only transiently perturbed (Lin et al., 2000), suggesting that the CNG channel may not be the sole target of cAMP. This prompted us to investigate an alternative channel, the hyperpolarization-activated, cyclic nucleotide-gated cation channel (HCN), as a potential developmental target of cAMP in OSNs. Here, we demonstrate that HCN channels are developmentally precocious in OSNs and therefore are plausible candidates for affecting OSN axon development. Inhibition of HCN channels in dissociated OSNs significantly reduced neurite outgrowth. Moreover, in HCN1 knock-out mice the formation of glomeruli was delayed in parallel with perturbations of axon organization in the olfactory nerve. These data support the hypothesis that the outgrowth and coalescence of OSN axons is, at least in part, subject to activity-dependent mechanisms mediated via HCN channels.
536 _ _ |0 G:(DE-Juel1)FUEK505
|2 G:(DE-HGF)
|a BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung
|c P45
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Animals, Newborn
650 _ 2 |2 MeSH
|a Antidiarrheals: pharmacology
650 _ 2 |2 MeSH
|a Axons: drug effects
650 _ 2 |2 MeSH
|a Axons: physiology
650 _ 2 |2 MeSH
|a Biophysics: methods
650 _ 2 |2 MeSH
|a Cardiotonic Agents: pharmacology
650 _ 2 |2 MeSH
|a Cells, Cultured
650 _ 2 |2 MeSH
|a Cyclic Nucleotide-Gated Cation Channels: deficiency
650 _ 2 |2 MeSH
|a Cyclic Nucleotide-Gated Cation Channels: physiology
650 _ 2 |2 MeSH
|a Electric Stimulation: methods
650 _ 2 |2 MeSH
|a Embryo, Mammalian
650 _ 2 |2 MeSH
|a GAP-43 Protein: metabolism
650 _ 2 |2 MeSH
|a Gene Expression Regulation, Developmental: drug effects
650 _ 2 |2 MeSH
|a Gene Expression Regulation, Developmental: physiology
650 _ 2 |2 MeSH
|a Green Fluorescent Proteins: genetics
650 _ 2 |2 MeSH
|a Ion Channels: genetics
650 _ 2 |2 MeSH
|a Ion Channels: metabolism
650 _ 2 |2 MeSH
|a Loperamide: pharmacology
650 _ 2 |2 MeSH
|a Membrane Potentials: drug effects
650 _ 2 |2 MeSH
|a Membrane Potentials: genetics
650 _ 2 |2 MeSH
|a Mice
650 _ 2 |2 MeSH
|a Mice, Inbred C57BL
650 _ 2 |2 MeSH
|a Mice, Knockout
650 _ 2 |2 MeSH
|a Neural Cell Adhesion Molecules: metabolism
650 _ 2 |2 MeSH
|a Neurogenesis: drug effects
650 _ 2 |2 MeSH
|a Neurogenesis: physiology
650 _ 2 |2 MeSH
|a Olfactory Bulb: cytology
650 _ 2 |2 MeSH
|a Olfactory Bulb: embryology
650 _ 2 |2 MeSH
|a Olfactory Bulb: growth & development
650 _ 2 |2 MeSH
|a Patch-Clamp Techniques: methods
650 _ 2 |2 MeSH
|a Potassium Channels: deficiency
650 _ 2 |2 MeSH
|a Potassium Channels: genetics
650 _ 2 |2 MeSH
|a Potassium Channels: metabolism
650 _ 2 |2 MeSH
|a Potassium Channels: physiology
650 _ 2 |2 MeSH
|a Pyrimidines: pharmacology
650 _ 2 |2 MeSH
|a Receptors, Odorant: genetics
650 _ 2 |2 MeSH
|a Receptors, Odorant: metabolism
650 _ 2 |2 MeSH
|a Sensory Receptor Cells: cytology
650 _ 2 |2 MeSH
|a Sensory Receptor Cells: drug effects
650 _ 7 |0 0
|2 NLM Chemicals
|a Antidiarrheals
650 _ 7 |0 0
|2 NLM Chemicals
|a Cardiotonic Agents
650 _ 7 |0 0
|2 NLM Chemicals
|a Cyclic Nucleotide-Gated Cation Channels
650 _ 7 |0 0
|2 NLM Chemicals
|a GAP-43 Protein
650 _ 7 |0 0
|2 NLM Chemicals
|a HCN2 potassium channel
650 _ 7 |0 0
|2 NLM Chemicals
|a HCN4 protein, rat
650 _ 7 |0 0
|2 NLM Chemicals
|a Ion Channels
650 _ 7 |0 0
|2 NLM Chemicals
|a Neural Cell Adhesion Molecules
650 _ 7 |0 0
|2 NLM Chemicals
|a Olfr1507 protein, mouse
650 _ 7 |0 0
|2 NLM Chemicals
|a Potassium Channels
650 _ 7 |0 0
|2 NLM Chemicals
|a Pyrimidines
650 _ 7 |0 0
|2 NLM Chemicals
|a Receptors, Odorant
650 _ 7 |0 0
|2 NLM Chemicals
|a hyperpolarization-activated cation channel
650 _ 7 |0 133059-99-1
|2 NLM Chemicals
|a ICI D2788
650 _ 7 |0 147336-22-9
|2 NLM Chemicals
|a Green Fluorescent Proteins
650 _ 7 |0 53179-11-6
|2 NLM Chemicals
|a Loperamide
650 _ 7 |2 WoSType
|a J
700 1 _ |0 P:(DE-HGF)0
|a Miller, A.M.
|b 1
700 1 _ |0 P:(DE-HGF)0
|a Araneda, R.C.
|b 2
700 1 _ |0 P:(DE-HGF)0
|a Maurer, L.R.
|b 3
700 1 _ |0 P:(DE-Juel1)131939
|a Müller, F.
|b 4
|u FZJ
700 1 _ |0 P:(DE-HGF)0
|a Greer, C.A.
|b 5
773 _ _ |0 PERI:(DE-600)1475274-8
|a 10.1523/JNEUROSCI.4225-10.2010
|g Vol. 30, p. 16498 - 16508
|p 16498 - 16508
|q 30<16498 - 16508
|t The @journal of neuroscience
|v 30
|x 0270-6474
|y 2010
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393111
909 C O |o oai:juser.fz-juelich.de:14281
|p VDB
913 1 _ |0 G:(DE-Juel1)FUEK505
|a DE-HGF
|b Schlüsseltechnologien
|k P45
|l Biologische Informationsverarbeitung
|v BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung
|x 0
913 2 _ |0 G:(DE-HGF)POF3-553
|1 G:(DE-HGF)POF3-550
|2 G:(DE-HGF)POF3-500
|a DE-HGF
|b Key Technologies
|l BioSoft Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences
|v Physical Basis of Diseases
|x 0
914 1 _ |y 2010
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |0 I:(DE-Juel1)VDB922
|g ISB
|k ISB-1
|l Zelluläre Biophysik
|x 0
970 _ _ |a VDB:(DE-Juel1)126328
980 _ _ |a VDB
980 _ _ |a ConvertedRecord
980 _ _ |a journal
980 _ _ |a I:(DE-Juel1)ICS-4-20110106
980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)IBI-1-20200312
981 _ _ |a I:(DE-Juel1)ICS-4-20110106

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21