Hauptseite > Publikationsdatenbank > Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors > print

001     14601
005     20200402210008.0
024 7 _ |2 pmid
|a pmid:21219903
024 7 _ |2 DOI
|a 10.1016/j.febslet.2010.12.042
024 7 _ |2 WOS
|a WOS:000286657700011
037 _ _ |a PreJuSER-14601
041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Biochemistry & Molecular Biology
084 _ _ |2 WoS
|a Biophysics
084 _ _ |2 WoS
|a Cell Biology
100 1 _ |0 P:(DE-HGF)0
|a Seebahn, A.
|b 0
245 _ _ |a Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors
260 _ _ |a Amsterdam [u.a.]
|b Elsevier
|c 2011
300 _ _ |a 511 - 516
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |0 2052
|a FEBS Letters
|v 585
|x 0014-5793
|y 3
500 _ _ |3 POF3_Assignment on 2016-02-29
500 _ _ |a We thank Wei Xiang for help with mass spectrometry and Dieter Willbold for helpful discussions. This work was supported by the Deutsche Forschungsgemeinschaft [EN349/5-2, EU-HEALTH-F4-2008-202088, SFB539, SFB796].
520 _ _ |a Metabotropic glutamate receptors (mGluRs) are regulated by interacting proteins that mostly bind to their intracellular C-termini. Here, we investigated if mGluR6, mGluR7a and mGluR8a C-termini form predefined binding surfaces or if they were rather unstructured. Limited tryptic digest of purified peptides argued against the formation of stable globular folds. Circular dichroism, (1)H NMR and (1)H(15)N HSQC spectra indicated the absence of rigid secondary structure elements. Furthermore, we localized short linear binding motifs in the unstructured receptor domains. Our data provide evidence that protein interactions of the analyzed mGluR C-termini are mediated rather by short linear motifs than by preformed folds.
536 _ _ |a Funktion und Dysfunktion des Nervensystems
|0 G:(DE-Juel1)FUEK409
|c P33
|2 G:(DE-HGF)
|x 0
536 _ _ |a BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung
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536 _ _ |a NEUROCYPRES - Neurotransmitter Cys-loop receptors: structure, function and disease (202088)
|0 G:(EU-Grant)202088
|c 202088
|x 2
|f FP7-HEALTH-2007-A
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Amino Acid Motifs
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Circular Dichroism
650 _ 2 |2 MeSH
|a Computational Biology: methods
650 _ 2 |2 MeSH
|a Nuclear Magnetic Resonance, Biomolecular
650 _ 2 |2 MeSH
|a Peptide Fragments: chemistry
650 _ 2 |2 MeSH
|a Peptide Fragments: metabolism
650 _ 2 |2 MeSH
|a Protein Folding
650 _ 2 |2 MeSH
|a Protein Hydrolysates: chemistry
650 _ 2 |2 MeSH
|a Protein Interaction Domains and Motifs
650 _ 2 |2 MeSH
|a Protein Isoforms: chemistry
650 _ 2 |2 MeSH
|a Protein Isoforms: metabolism
650 _ 2 |2 MeSH
|a Protein Structure, Secondary
650 _ 2 |2 MeSH
|a Rats
650 _ 2 |2 MeSH
|a Receptors, Metabotropic Glutamate: chemistry
650 _ 2 |2 MeSH
|a Receptors, Metabotropic Glutamate: genetics
650 _ 2 |2 MeSH
|a Receptors, Metabotropic Glutamate: metabolism
650 _ 2 |2 MeSH
|a Recombinant Fusion Proteins: chemistry
650 _ 2 |2 MeSH
|a Recombinant Fusion Proteins: metabolism
650 _ 2 |2 MeSH
|a Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
650 _ 7 |0 0
|2 NLM Chemicals
|a Peptide Fragments
650 _ 7 |0 0
|2 NLM Chemicals
|a Protein Hydrolysates
650 _ 7 |0 0
|2 NLM Chemicals
|a Protein Isoforms
650 _ 7 |0 0
|2 NLM Chemicals
|a Receptors, Metabotropic Glutamate
650 _ 7 |0 0
|2 NLM Chemicals
|a Recombinant Fusion Proteins
650 _ 7 |0 0
|2 NLM Chemicals
|a metabotropic glutamate receptor 6
650 _ 7 |0 0
|2 NLM Chemicals
|a metabotropic glutamate receptor 7
650 _ 7 |0 0
|2 NLM Chemicals
|a metabotropic glutamate receptor 8
650 _ 7 |2 WoSType
|a J
653 2 0 |2 Author
|a G-protein coupled receptor
653 2 0 |2 Author
|a Metabotropic glutamate receptor
653 2 0 |2 Author
|a Neurotransmitter receptor
653 2 0 |2 Author
|a Short linear motif
700 1 _ |0 P:(DE-HGF)0
|a Dinkel, H.
|b 1
700 1 _ |0 P:(DE-Juel1)132012
|a Mohrlüder, J.
|b 2
|u FZJ
700 1 _ |0 P:(DE-Juel1)VDB57647
|a Hartmann, R.
|b 3
|u FZJ
700 1 _ |0 P:(DE-HGF)0
|a Vogel, N.
|b 4
700 1 _ |0 P:(DE-HGF)0
|a Becker, C.M.
|b 5
700 1 _ |0 P:(DE-HGF)0
|a Sticht, H.
|b 6
700 1 _ |0 P:(DE-HGF)0
|a Enz, R.
|b 7
773 _ _ |0 PERI:(DE-600)1460391-3
|a 10.1016/j.febslet.2010.12.042
|g Vol. 585, p. 511 - 516
|p 511 - 516
|q 585<511 - 516
|t FEBS letters
|v 585
|x 0014-5793
|y 2011
856 7 _ |u http://dx.doi.org/10.1016/j.febslet.2010.12.042
909 C O |o oai:juser.fz-juelich.de:14601
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914 1 _ |y 2011
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