000014888 001__ 14888
000014888 005__ 20210129210616.0
000014888 0247_ $$2pmid$$apmid:21442415
000014888 0247_ $$2DOI$$a10.1007/s00429-011-0303-3
000014888 0247_ $$2WOS$$aWOS:000293924300004
000014888 037__ $$aPreJuSER-14888
000014888 041__ $$aeng
000014888 082__ $$a610
000014888 084__ $$2WoS$$aAnatomy & Morphology
000014888 084__ $$2WoS$$aNeurosciences
000014888 1001_ $$0P:(DE-Juel1)VDB71164$$aCremer, C.M.$$b0$$uFZJ
000014888 245__ $$aLaminar distribution of neurotransmitter receptors in different reeler mouse brain regions
000014888 260__ $$aBerlin$$bSpringer$$c2011
000014888 300__ $$a201 - 218
000014888 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000014888 3367_ $$2DataCite$$aOutput Types/Journal article
000014888 3367_ $$00$$2EndNote$$aJournal Article
000014888 3367_ $$2BibTeX$$aARTICLE
000014888 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000014888 3367_ $$2DRIVER$$aarticle
000014888 440_0 $$017221$$aBrain Structure & Function$$v216$$x1863-2653$$y3
000014888 500__ $$aThe excellent technical assistance by S. Buller, M. Cremer and S. Wilms is very much appreciated. We further thank Dr. Axel Schleicher for helpful comments on the data, and Drs. Iris Hack and Astrid Rollenhagen for their critical reading and comments on the final version of the manuscript. This work was supported by the Initiative and Networking Fund of the Helmholtz Association (Helmholtz Alliance on Mental Health in an Ageing Society).
000014888 520__ $$aMapping of multiple receptors of neurotransmitters provides insight into the spatial distribution of neurotransmission-relevant molecules in the cerebral cortex. During development, lack of reelin leads to impaired migration, disturbed lamination of the hippocampus and inverted neocortical layering. In the adult, reelin may regulate synaptic plasticity by modulating neurotransmitter receptor function. Using quantitative in vitro receptor autoradiography, different receptors, in particular, the binding site densities and laminar distribution of various glutamate, GABA, muscarinic and nicotinic acetylcholine, serotonin, dopamine and adenosine receptors, were analyzed in cortical and subcortical structures of reeler and wild-type brains. Differential changes in the laminar distribution, maximum binding capacity (B (max)) and regional density of neurotransmitter receptors were found in the reeler brain. A decrease of whole brain B (max) was found for adenosine A(1) and GABA(A) receptors. In the forebrain, several binding sites were differentially up- or down-regulated (kainate, A(1), benzodiazepine, 5-HT(1), M(2), α(1) and α(2)). In the hippocampus, a significant decrease of GABA(B), 5-HT(1) and A'₁ receptors were observed. The density of M(2) receptors increased, while other receptors remained unchanged. In the neocortex, some receptors demonstrated an obviously inverted laminar distribution (AMPA, kainate, NMDA, GABA(B), 5-HT(1), M(1), M(3), nAch), while the distribution of others (A(1), GABA(A), benzodiazepine, 5-HT(2), muscarinic M(2), adrenergic α(1), α(2)) seemed to be less affected. Thus, the laminar receptor distribution is modulated by the developmental impairment and suggests and reflects partially the laminar inversion in reeler mice.
000014888 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000014888 536__ $$0G:(DE-HGF)POF2-89571$$a89571 - Connectivity and Activity (POF2-89571)$$cPOF2-89571$$fPOF II T$$x1
000014888 588__ $$aDataset connected to Web of Science, Pubmed
000014888 650_2 $$2MeSH$$aAnalysis of Variance
000014888 650_2 $$2MeSH$$aAnimals
000014888 650_2 $$2MeSH$$aAutoradiography
000014888 650_2 $$2MeSH$$aBrain: anatomy & histology
000014888 650_2 $$2MeSH$$aBrain: metabolism
000014888 650_2 $$2MeSH$$aBrain Mapping: methods
000014888 650_2 $$2MeSH$$aCell Adhesion Molecules, Neuronal: deficiency
000014888 650_2 $$2MeSH$$aDensitometry
000014888 650_2 $$2MeSH$$aExtracellular Matrix Proteins: deficiency
000014888 650_2 $$2MeSH$$aImage Processing, Computer-Assisted
000014888 650_2 $$2MeSH$$aMale
000014888 650_2 $$2MeSH$$aMice
000014888 650_2 $$2MeSH$$aMice, Neurologic Mutants: anatomy & histology
000014888 650_2 $$2MeSH$$aMice, Neurologic Mutants: metabolism
000014888 650_2 $$2MeSH$$aNerve Tissue Proteins: deficiency
000014888 650_2 $$2MeSH$$aRadioligand Assay
000014888 650_2 $$2MeSH$$aReceptors, Neurotransmitter: metabolism
000014888 650_2 $$2MeSH$$aRegression Analysis
000014888 650_2 $$2MeSH$$aSerine Endopeptidases: deficiency
000014888 650_2 $$2MeSH$$aSynaptic Transmission: physiology
000014888 650_7 $$00$$2NLM Chemicals$$aCell Adhesion Molecules, Neuronal
000014888 650_7 $$00$$2NLM Chemicals$$aExtracellular Matrix Proteins
000014888 650_7 $$00$$2NLM Chemicals$$aNerve Tissue Proteins
000014888 650_7 $$00$$2NLM Chemicals$$aReceptors, Neurotransmitter
000014888 650_7 $$0EC 3.4.21.-$$2NLM Chemicals$$aSerine Endopeptidases
000014888 650_7 $$0EC 3.4.21.-$$2NLM Chemicals$$areelin protein
000014888 650_7 $$2WoSType$$aJ
000014888 65320 $$2Author$$aReeler mouse
000014888 65320 $$2Author$$aQuantitative receptor autoradiography
000014888 65320 $$2Author$$aNeurotransmitter receptor mapping
000014888 65320 $$2Author$$aCortical organization
000014888 65320 $$2Author$$aSynaptic transmission and plasticity
000014888 7001_ $$0P:(DE-Juel1)VDB86960$$aLübke, J.H.R.$$b1$$uFZJ
000014888 7001_ $$0P:(DE-Juel1)VDB1208$$aPalomero-Gallagher, N.$$b2$$uFZJ
000014888 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b3$$uFZJ
000014888 773__ $$0PERI:(DE-600)2303775-1$$a10.1007/s00429-011-0303-3$$gVol. 216, p. 201 - 218$$p201 - 218$$q216<201 - 218$$tBrain structure & function$$v216$$x1863-2653$$y2011
000014888 8567_ $$uhttp://dx.doi.org/10.1007/s00429-011-0303-3
000014888 909CO $$ooai:juser.fz-juelich.de:14888$$pVDB
000014888 9132_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000014888 9131_ $$0G:(DE-HGF)POF2-89571$$1G:(DE-HGF)POF3-890$$2G:(DE-HGF)POF3-800$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vConnectivity and Activity$$x1
000014888 9141_ $$y2011
000014888 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000014888 9201_ $$0I:(DE-Juel1)INM-2-20090406$$gINM$$kINM-2$$lMolekulare Organisation des Gehirns$$x0
000014888 970__ $$aVDB:(DE-Juel1)127385
000014888 980__ $$aVDB
000014888 980__ $$aConvertedRecord
000014888 980__ $$ajournal
000014888 980__ $$aI:(DE-Juel1)INM-2-20090406
000014888 980__ $$aUNRESTRICTED