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@ARTICLE{Cremer:14888,
      author       = {Cremer, C.M. and Lübke, J.H.R. and Palomero-Gallagher, N.
                      and Zilles, K.},
      title        = {{L}aminar distribution of neurotransmitter receptors in
                      different reeler mouse brain regions},
      journal      = {Brain structure $\&$ function},
      volume       = {216},
      issn         = {1863-2653},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {PreJuSER-14888},
      pages        = {201 - 218},
      year         = {2011},
      note         = {The excellent technical assistance by S. Buller, M. Cremer
                      and S. Wilms is very much appreciated. We further thank Dr.
                      Axel Schleicher for helpful comments on the data, and Drs.
                      Iris Hack and Astrid Rollenhagen for their critical reading
                      and comments on the final version of the manuscript. This
                      work was supported by the Initiative and Networking Fund of
                      the Helmholtz Association (Helmholtz Alliance on Mental
                      Health in an Ageing Society).},
      abstract     = {Mapping of multiple receptors of neurotransmitters provides
                      insight into the spatial distribution of
                      neurotransmission-relevant molecules in the cerebral cortex.
                      During development, lack of reelin leads to impaired
                      migration, disturbed lamination of the hippocampus and
                      inverted neocortical layering. In the adult, reelin may
                      regulate synaptic plasticity by modulating neurotransmitter
                      receptor function. Using quantitative in vitro receptor
                      autoradiography, different receptors, in particular, the
                      binding site densities and laminar distribution of various
                      glutamate, GABA, muscarinic and nicotinic acetylcholine,
                      serotonin, dopamine and adenosine receptors, were analyzed
                      in cortical and subcortical structures of reeler and
                      wild-type brains. Differential changes in the laminar
                      distribution, maximum binding capacity (B (max)) and
                      regional density of neurotransmitter receptors were found in
                      the reeler brain. A decrease of whole brain B (max) was
                      found for adenosine A(1) and GABA(A) receptors. In the
                      forebrain, several binding sites were differentially up- or
                      down-regulated (kainate, A(1), benzodiazepine, 5-HT(1),
                      M(2), α(1) and α(2)). In the hippocampus, a significant
                      decrease of GABA(B), 5-HT(1) and A'₁ receptors were
                      observed. The density of M(2) receptors increased, while
                      other receptors remained unchanged. In the neocortex, some
                      receptors demonstrated an obviously inverted laminar
                      distribution (AMPA, kainate, NMDA, GABA(B), 5-HT(1), M(1),
                      M(3), nAch), while the distribution of others (A(1),
                      GABA(A), benzodiazepine, 5-HT(2), muscarinic M(2),
                      adrenergic α(1), α(2)) seemed to be less affected. Thus,
                      the laminar receptor distribution is modulated by the
                      developmental impairment and suggests and reflects partially
                      the laminar inversion in reeler mice.},
      keywords     = {Analysis of Variance / Animals / Autoradiography / Brain:
                      anatomy $\&$ histology / Brain: metabolism / Brain Mapping:
                      methods / Cell Adhesion Molecules, Neuronal: deficiency /
                      Densitometry / Extracellular Matrix Proteins: deficiency /
                      Image Processing, Computer-Assisted / Male / Mice / Mice,
                      Neurologic Mutants: anatomy $\&$ histology / Mice,
                      Neurologic Mutants: metabolism / Nerve Tissue Proteins:
                      deficiency / Radioligand Assay / Receptors,
                      Neurotransmitter: metabolism / Regression Analysis / Serine
                      Endopeptidases: deficiency / Synaptic Transmission:
                      physiology / Cell Adhesion Molecules, Neuronal (NLM
                      Chemicals) / Extracellular Matrix Proteins (NLM Chemicals) /
                      Nerve Tissue Proteins (NLM Chemicals) / Receptors,
                      Neurotransmitter (NLM Chemicals) / Serine Endopeptidases
                      (NLM Chemicals) / reelin protein (NLM Chemicals) / J
                      (WoSType)},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Anatomy $\&$ Morphology / Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21442415},
      UT           = {WOS:000293924300004},
      doi          = {10.1007/s00429-011-0303-3},
      url          = {https://juser.fz-juelich.de/record/14888},
}