Home > Publications database > Laminar distribution of neurotransmitter receptors in different reeler mouse brain regions > print

001     14888
005     20210129210616.0
024 7 _ |2 pmid
|a pmid:21442415
024 7 _ |2 DOI
|a 10.1007/s00429-011-0303-3
024 7 _ |2 WOS
|a WOS:000293924300004
037 _ _ |a PreJuSER-14888
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Anatomy & Morphology
084 _ _ |2 WoS
|a Neurosciences
100 1 _ |a Cremer, C.M.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB71164
245 _ _ |a Laminar distribution of neurotransmitter receptors in different reeler mouse brain regions
260 _ _ |a Berlin
|b Springer
|c 2011
300 _ _ |a 201 - 218
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Brain Structure & Function
|x 1863-2653
|0 17221
|y 3
|v 216
500 _ _ |a The excellent technical assistance by S. Buller, M. Cremer and S. Wilms is very much appreciated. We further thank Dr. Axel Schleicher for helpful comments on the data, and Drs. Iris Hack and Astrid Rollenhagen for their critical reading and comments on the final version of the manuscript. This work was supported by the Initiative and Networking Fund of the Helmholtz Association (Helmholtz Alliance on Mental Health in an Ageing Society).
520 _ _ |a Mapping of multiple receptors of neurotransmitters provides insight into the spatial distribution of neurotransmission-relevant molecules in the cerebral cortex. During development, lack of reelin leads to impaired migration, disturbed lamination of the hippocampus and inverted neocortical layering. In the adult, reelin may regulate synaptic plasticity by modulating neurotransmitter receptor function. Using quantitative in vitro receptor autoradiography, different receptors, in particular, the binding site densities and laminar distribution of various glutamate, GABA, muscarinic and nicotinic acetylcholine, serotonin, dopamine and adenosine receptors, were analyzed in cortical and subcortical structures of reeler and wild-type brains. Differential changes in the laminar distribution, maximum binding capacity (B (max)) and regional density of neurotransmitter receptors were found in the reeler brain. A decrease of whole brain B (max) was found for adenosine A(1) and GABA(A) receptors. In the forebrain, several binding sites were differentially up- or down-regulated (kainate, A(1), benzodiazepine, 5-HT(1), M(2), α(1) and α(2)). In the hippocampus, a significant decrease of GABA(B), 5-HT(1) and A'₁ receptors were observed. The density of M(2) receptors increased, while other receptors remained unchanged. In the neocortex, some receptors demonstrated an obviously inverted laminar distribution (AMPA, kainate, NMDA, GABA(B), 5-HT(1), M(1), M(3), nAch), while the distribution of others (A(1), GABA(A), benzodiazepine, 5-HT(2), muscarinic M(2), adrenergic α(1), α(2)) seemed to be less affected. Thus, the laminar receptor distribution is modulated by the developmental impairment and suggests and reflects partially the laminar inversion in reeler mice.
536 _ _ |0 G:(DE-Juel1)FUEK409
|2 G:(DE-HGF)
|x 0
|c FUEK409
|a Funktion und Dysfunktion des Nervensystems (FUEK409)
536 _ _ |a 89571 - Connectivity and Activity (POF2-89571)
|0 G:(DE-HGF)POF2-89571
|c POF2-89571
|x 1
|f POF II T
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Analysis of Variance
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Autoradiography
650 _ 2 |2 MeSH
|a Brain: anatomy & histology
650 _ 2 |2 MeSH
|a Brain: metabolism
650 _ 2 |2 MeSH
|a Brain Mapping: methods
650 _ 2 |2 MeSH
|a Cell Adhesion Molecules, Neuronal: deficiency
650 _ 2 |2 MeSH
|a Densitometry
650 _ 2 |2 MeSH
|a Extracellular Matrix Proteins: deficiency
650 _ 2 |2 MeSH
|a Image Processing, Computer-Assisted
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Mice
650 _ 2 |2 MeSH
|a Mice, Neurologic Mutants: anatomy & histology
650 _ 2 |2 MeSH
|a Mice, Neurologic Mutants: metabolism
650 _ 2 |2 MeSH
|a Nerve Tissue Proteins: deficiency
650 _ 2 |2 MeSH
|a Radioligand Assay
650 _ 2 |2 MeSH
|a Receptors, Neurotransmitter: metabolism
650 _ 2 |2 MeSH
|a Regression Analysis
650 _ 2 |2 MeSH
|a Serine Endopeptidases: deficiency
650 _ 2 |2 MeSH
|a Synaptic Transmission: physiology
650 _ 7 |0 0
|2 NLM Chemicals
|a Cell Adhesion Molecules, Neuronal
650 _ 7 |0 0
|2 NLM Chemicals
|a Extracellular Matrix Proteins
650 _ 7 |0 0
|2 NLM Chemicals
|a Nerve Tissue Proteins
650 _ 7 |0 0
|2 NLM Chemicals
|a Receptors, Neurotransmitter
650 _ 7 |0 EC 3.4.21.-
|2 NLM Chemicals
|a Serine Endopeptidases
650 _ 7 |0 EC 3.4.21.-
|2 NLM Chemicals
|a reelin protein
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a Reeler mouse
653 2 0 |2 Author
|a Quantitative receptor autoradiography
653 2 0 |2 Author
|a Neurotransmitter receptor mapping
653 2 0 |2 Author
|a Cortical organization
653 2 0 |2 Author
|a Synaptic transmission and plasticity
700 1 _ |a Lübke, J.H.R.
|b 1
|u FZJ
|0 P:(DE-Juel1)VDB86960
700 1 _ |a Palomero-Gallagher, N.
|b 2
|u FZJ
|0 P:(DE-Juel1)VDB1208
700 1 _ |a Zilles, K.
|b 3
|u FZJ
|0 P:(DE-Juel1)131714
773 _ _ |a 10.1007/s00429-011-0303-3
|g Vol. 216, p. 201 - 218
|p 201 - 218
|q 216<201 - 218
|0 PERI:(DE-600)2303775-1
|t Brain structure & function
|v 216
|y 2011
|x 1863-2653
856 7 _ |u http://dx.doi.org/10.1007/s00429-011-0303-3
909 C O |o oai:juser.fz-juelich.de:14888
|p VDB
913 2 _ |a DE-HGF
|b Key Technologies
|l Decoding the Human Brain
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|v Connectivity and Activity
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913 1 _ |a DE-HGF
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|b Programmungebundene Forschung
|l ohne Programm
914 1 _ |y 2011
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k INM-2
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970 _ _ |a VDB:(DE-Juel1)127385
980 _ _ |a VDB
980 _ _ |a ConvertedRecord
980 _ _ |a journal
980 _ _ |a I:(DE-Juel1)INM-2-20090406
980 _ _ |a UNRESTRICTED

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