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| Hauptseite > Publikationsdatenbank > Heterogeneous structure, function and connectivity of the human subgenual anterior cingulate cortex |
| Hauptseite > Publikationsdatenbank > Heterogeneous structure, function and connectivity of the human subgenual anterior cingulate cortex |
| Abstract | FZJ-2014-01163 |
2014
Abstract: Introduction:The subgenual anterior cingulate cortex (sACC) is involved in the processing of affective experiencesassociated with sadness1, and the down-regulation of negative affective responses leading to fearextinction2. However, the functional diversity as found in neuroimaging studies does not match themacroscopic concept of a homogeneous sACC, and cannot be considered synonymous of Brodmann'sarea 25 either. Rather, the sACC is a cytoarchitectonically heterogeneous brain region and encompassesareas 25, s24 and s32, as well as the most ventral portion of area 333. Here we present data, whichrelates the cytoarchitectonic heterogeneity of sACC with its function and connectivity.Methods:Cytoarchitectonically characterized areas 25, s24, s32 and 333 were 3-D-reconstructed in 10 brains andspatially normalized to the single-subject template of the Montreal Neurological Institute (Colin27) forcomputation of probabilistic maps and maximum probability maps (MPM) of each area. These standardspace representations were then used to investigate the task-dependent functional connectivity profilesof sACC areas and their functional associations using meta-analytic connectivity modelling (MACM)4 andquantitative functional decoding5, respectively, applying the BrainMap database. Additionally, weassessed hemisphere- and gender-related differences in the volumes sACC areas bycytoarchitectonically informed voxel-based morphometry in a cohort of 102 right-handed healthyvolunteers.Results:The MACM analysis revealed different co-activation patterns with a widespread network of cortical andsubcortical structures for each of the examined areas, with only a minimal degree of overlap. Thequantitative behavioural characterization revealed that although areas s24, s32 and 33 share a commonfunctional profile related to cognition, emotion and perception, they can be individually associated withdifferentiable functional processes. Area s24 was specifically associated with the processing of sadness,area s32 with that of fear. In addition, both were associated with taste perception. They bothco-activated with frontopolar area Fp2 and the amygdala, i.e., parts of the affective network6, and withthe ventral posterior cingulate cortex (PCC). Area s32 also co-activated with areas PGp and 47, i.e. withpart of the executive control network7, and was associated with tasks cognitive tasks involvingnon-affective stimuli. Area 25 co-activated with PFt, hOc2, the pregenual ACC and the cerebellar vermis.Interestingly, area 25 could not be associated with a specific domain, indicating that either thesustained functions are not represented in psychological domains as covered by BrainMap, or that area25 is associated with so many of them, that an above chance probability could not be determined forany given functional domain. Area 33 was involved in the perception of pain, and co-activated with areas of the sensorimotor network8 such as areas 6, OP 1 or PFop, as well as with the dorsal PCC, theamygdala and thalamus. We found no hemisphere- or gender-related differences in the volumes ofsACC areas.
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