TY  - CHAP
AU  - Elmenhorst, David
AU  - Bier, Dirk
AU  - Holschbach, Marcus
AU  - Bauer, Andreas
TI  - Imaging of Adenosine Receptors; Chapter 7
CY  - Berlin, Heidelberg
PB  - Springer Berlin Heidelberg
M1  - FZJ-2014-01650
SN  - 978-3-642-42013-9
SP  - 181-198
PY  - 2014
AB  - Adenosine is a fundamental molecule of life. It is a part of the DNA and the main degradation product of the central currency of energy metabolism in humans and animals – adenosine triphosphate (ATP). Under pathological conditions like hypoxia, the adenosine concentration can rise severalfold – up to micromolar concentrations. The net effect of adenosine on excitable tissue is inhibitory affecting the release of classical neurotransmitters like glutamate, GABA (gamma-aminobutyric acid), and dopamine. The widely used neurostimulant caffeine exerts its effects as an antagonist at adenosine receptors. Four different types of adenosine receptors have been described in mammals: A1, A2A, A2B, and A3 which are all G-protein-coupled receptors. Over the last 25 years, adenosine receptor ligands, agonists as well as antagonists, have emerged as a class of useful therapeutics. For the A1 and A2A subtypes several antagonist radioligands have been used successfully for PET imaging in humans and animals especially for the brain.
LB  - PUB:(DE-HGF)7
DO  - DOI:10.1007/978-3-642-42014-6_7
UR  - https://juser.fz-juelich.de/record/151761
ER  -