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000151781 0247_ $$2doi$$a10.1007/s11307-014-0729-0
000151781 0247_ $$2ISSN$$a1536-1632
000151781 0247_ $$2ISSN$$a1860-2002
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000151781 037__ $$aFZJ-2014-01663
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000151781 1001_ $$0P:(DE-Juel1)131691$$aKroll, Tina$$b0$$eCorresponding author$$ufzj
000151781 245__ $$aReproducibility of Non-Invasive A1 Adenosine Receptor Quantification in the Rat Brain Using [18F]CPFPX and Positron Emission Tomography
000151781 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2014
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000151781 520__ $$aPurposeThe A1AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([18F]CPFPX) has recently been shown to be a suitable radiotracer for quantitative in vivo imaging of the A1 adenosine receptor (A1AR) in rats. The present study evaluates the reproducibility of non-invasive longitudinal A1AR studies with [18F]CPFPX and a dedicated small animal positron emission tomography (PET) scanner.ProceduresTwelve male Sprague Dawley rats underwent four repeated dynamic PET scans with a bolus injection of [18F]CPFPX. A1AR availability was determined by different non-invasive approaches including simplified and multilinear reference tissue (olfactory bulb)-based models and graphical methods. The outcome parameter binding potential (BP) was evaluated in terms of variability and reproducibility.ResultsRepeated estimations of [18F]CPFPX BP ND gave reliable results with acceptable variability (mean 12 %) and reproducibility (intraclass correlation coefficients raging from 0.57 to 0.68) in cortical and subcortical regions of the rat brain. With regard to kinetic models, test-retest stability of the simplified reference-tissue model (SRTM) was superior to multilinear and graphical approaches.ConclusionsNon-invasive quantification of A1AR density in the rat brain is reproducible and reliable with [18F]CPFPX PET and allows longitudinal designs of in vivo imaging studies in rodents.
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000151781 7001_ $$0P:(DE-Juel1)131679$$aElmenhorst, David$$b1$$ufzj
000151781 7001_ $$0P:(DE-Juel1)131712$$aWeißhaupt, Angela$$b2$$ufzj
000151781 7001_ $$0P:(DE-Juel1)133864$$aBeer, Simone$$b3$$ufzj
000151781 7001_ $$0P:(DE-Juel1)131672$$aBauer, Andreas$$b4$$ufzj
000151781 773__ $$0PERI:(DE-600)2079211-6$$a10.1007/s11307-014-0729-0$$n5$$p699-709$$tMolecular imaging & biology$$v16$$x1536-1632$$y2014
000151781 8564_ $$uhttp://link.springer.com/article/10.1007%2Fs11307-014-0729-0
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