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@ARTICLE{Kroll:151781,
      author       = {Kroll, Tina and Elmenhorst, David and Weißhaupt, Angela
                      and Beer, Simone and Bauer, Andreas},
      title        = {{R}eproducibility of {N}on-{I}nvasive {A}1 {A}denosine
                      {R}eceptor {Q}uantification in the {R}at {B}rain {U}sing
                      [18{F}]{CPFPX} and {P}ositron {E}mission {T}omography},
      journal      = {Molecular imaging $\&$ biology},
      volume       = {16},
      number       = {5},
      issn         = {1536-1632},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2014-01663},
      pages        = {699-709},
      year         = {2014},
      abstract     = {PurposeThe A1AR antagonist
                      8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine
                      ([18F]CPFPX) has recently been shown to be a suitable
                      radiotracer for quantitative in vivo imaging of the A1
                      adenosine receptor (A1AR) in rats. The present study
                      evaluates the reproducibility of non-invasive longitudinal
                      A1AR studies with [18F]CPFPX and a dedicated small animal
                      positron emission tomography (PET) scanner.ProceduresTwelve
                      male Sprague Dawley rats underwent four repeated dynamic PET
                      scans with a bolus injection of [18F]CPFPX. A1AR
                      availability was determined by different non-invasive
                      approaches including simplified and multilinear reference
                      tissue (olfactory bulb)-based models and graphical methods.
                      The outcome parameter binding potential (BP) was evaluated
                      in terms of variability and reproducibility.ResultsRepeated
                      estimations of [18F]CPFPX BP ND gave reliable results with
                      acceptable variability (mean 12 $\%)$ and reproducibility
                      (intraclass correlation coefficients raging from 0.57 to
                      0.68) in cortical and subcortical regions of the rat brain.
                      With regard to kinetic models, test-retest stability of the
                      simplified reference-tissue model (SRTM) was superior to
                      multilinear and graphical approaches.ConclusionsNon-invasive
                      quantification of A1AR density in the rat brain is
                      reproducible and reliable with [18F]CPFPX PET and allows
                      longitudinal designs of in vivo imaging studies in rodents.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89571 - Connectivity and
                      Activity (POF2-89571)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000342135800014},
      doi          = {10.1007/s11307-014-0729-0},
      url          = {https://juser.fz-juelich.de/record/151781},
}