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| Home > Publications database > Reproducibility of Non-Invasive A1 Adenosine Receptor Quantification in the Rat Brain Using [18F]CPFPX and Positron Emission Tomography > print |
| 001 | 151781 | ||
| 005 | 20220930130027.0 | ||
| 024 | 7 | _ | |a 10.1007/s11307-014-0729-0 |2 doi |
| 024 | 7 | _ | |a 1536-1632 |2 ISSN |
| 024 | 7 | _ | |a 1860-2002 |2 ISSN |
| 024 | 7 | _ | |a WOS:000342135800014 |2 WOS |
| 037 | _ | _ | |a FZJ-2014-01663 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Kroll, Tina |0 P:(DE-Juel1)131691 |b 0 |e Corresponding author |u fzj |
| 245 | _ | _ | |a Reproducibility of Non-Invasive A1 Adenosine Receptor Quantification in the Rat Brain Using [18F]CPFPX and Positron Emission Tomography |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2014 |b Elsevier Science |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1415699082_4053 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a article |2 DRIVER |
| 520 | _ | _ | |a PurposeThe A1AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([18F]CPFPX) has recently been shown to be a suitable radiotracer for quantitative in vivo imaging of the A1 adenosine receptor (A1AR) in rats. The present study evaluates the reproducibility of non-invasive longitudinal A1AR studies with [18F]CPFPX and a dedicated small animal positron emission tomography (PET) scanner.ProceduresTwelve male Sprague Dawley rats underwent four repeated dynamic PET scans with a bolus injection of [18F]CPFPX. A1AR availability was determined by different non-invasive approaches including simplified and multilinear reference tissue (olfactory bulb)-based models and graphical methods. The outcome parameter binding potential (BP) was evaluated in terms of variability and reproducibility.ResultsRepeated estimations of [18F]CPFPX BP ND gave reliable results with acceptable variability (mean 12 %) and reproducibility (intraclass correlation coefficients raging from 0.57 to 0.68) in cortical and subcortical regions of the rat brain. With regard to kinetic models, test-retest stability of the simplified reference-tissue model (SRTM) was superior to multilinear and graphical approaches.ConclusionsNon-invasive quantification of A1AR density in the rat brain is reproducible and reliable with [18F]CPFPX PET and allows longitudinal designs of in vivo imaging studies in rodents. |
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| 700 | 1 | _ | |a Elmenhorst, David |0 P:(DE-Juel1)131679 |b 1 |u fzj |
| 700 | 1 | _ | |a Weißhaupt, Angela |0 P:(DE-Juel1)131712 |b 2 |u fzj |
| 700 | 1 | _ | |a Beer, Simone |0 P:(DE-Juel1)133864 |b 3 |u fzj |
| 700 | 1 | _ | |a Bauer, Andreas |0 P:(DE-Juel1)131672 |b 4 |u fzj |
| 773 | _ | _ | |a 10.1007/s11307-014-0729-0 |0 PERI:(DE-600)2079211-6 |n 5 |p 699-709 |t Molecular imaging & biology |v 16 |y 2014 |x 1536-1632 |
| 856 | 4 | _ | |u http://link.springer.com/article/10.1007%2Fs11307-014-0729-0 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/151781/files/FZJ-2014-01663.pdf |y Restricted |
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