TY  - JOUR
AU  - Püttmann, Andreas
AU  - Nicolai, Mike
AU  - Behr, Marek
AU  - von Lieres, Eric
TI  - Stabilized space–time finite elements for high-definition simulation of packed bed chromatography
JO  - Finite elements in analysis and design
VL  - 86
SN  - 0168-874X
CY  - Amsterdam
PB  - North-Holland
M1  - FZJ-2014-02939
SP  - 1 - 11
PY  - 2014
AB  - We present a finite element scheme for spatially resolved simulations of fluid flow and mass transfer in chromatography columns. Packed bed chromatography is an important unit operation for the purification of product molecules in biopharmaceutical industry. The problem combines different challenges arising from advection dominance, stiffness due to the presence of reaction terms, and from the size of the resulting linear equation systems. We show that our stabilized space–time finite element method can handle these difficulties adequately and solve test problems efficiently.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000336457200001
DO  - DOI:10.1016/j.finel.2014.03.001
UR  - https://juser.fz-juelich.de/record/153296
ER  -