Journal Article

FZJ-2014-02939

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Stabilized space–time finite elements for high-definition simulation of packed bed chromatography

Püttmann, A. (Corresponding Author)FZJ* ; Nicolai, M.FZJ* ; Behr, M. ; von Lieres, E.FZJ*

2014
North-Holland Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.finel.2014.03.001

Abstract: We present a finite element scheme for spatially resolved simulations of fluid flow and mass transfer in chromatography columns. Packed bed chromatography is an important unit operation for the purification of product molecules in biopharmaceutical industry. The problem combines different challenges arising from advection dominance, stiffness due to the presence of reaction terms, and from the size of the resulting linear equation systems. We show that our stabilized space–time finite element method can handle these difficulties adequately and solve test problems efficiently.

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Contributing Institute(s):

1. Biotechnologie (IBG-1)
2. Jülich Supercomputing Center (JSC)

Research Program(s):

1. 411 - Computational Science and Mathematical Methods (POF2-411) (POF2-411)

Appears in the scientific report 2014

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Database coverage:
; Current Contents - Social and Behavioral Sciences ; JCR ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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