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@ARTICLE{Pttmann:153296,
      author       = {Püttmann, Andreas and Nicolai, Mike and Behr, Marek and
                      von Lieres, Eric},
      title        = {{S}tabilized space–time finite elements for
                      high-definition simulation of packed bed chromatography},
      journal      = {Finite elements in analysis and design},
      volume       = {86},
      issn         = {0168-874X},
      address      = {Amsterdam},
      publisher    = {North-Holland},
      reportid     = {FZJ-2014-02939},
      pages        = {1 - 11},
      year         = {2014},
      abstract     = {We present a finite element scheme for spatially resolved
                      simulations of fluid flow and mass transfer in
                      chromatography columns. Packed bed chromatography is an
                      important unit operation for the purification of product
                      molecules in biopharmaceutical industry. The problem
                      combines different challenges arising from advection
                      dominance, stiffness due to the presence of reaction terms,
                      and from the size of the resulting linear equation systems.
                      We show that our stabilized space–time finite element
                      method can handle these difficulties adequately and solve
                      test problems efficiently.},
      cin          = {IBG-1 / JSC},
      ddc          = {510},
      cid          = {I:(DE-Juel1)IBG-1-20101118 / I:(DE-Juel1)JSC-20090406},
      pnm          = {411 - Computational Science and Mathematical Methods
                      (POF2-411)},
      pid          = {G:(DE-HGF)POF2-411},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000336457200001},
      doi          = {10.1016/j.finel.2014.03.001},
      url          = {https://juser.fz-juelich.de/record/153296},
}