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000015400 0247_ $$2pmid$$apmid:21753116
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000015400 0247_ $$2DOI$$a10.1104/pp.111.180422
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000015400 084__ $$2WoS$$aPlant Sciences
000015400 1001_ $$0P:(DE-HGF)0$$aDelatte, T.L.$$b0
000015400 245__ $$aGrowth arrest by trehalose-6-phosphate: an astonishing case of primary metabolite control over growth by way of the SnRK1 signaling pathway
000015400 260__ $$aRockville, Md.: Soc.$$bJSTOR$$c2011
000015400 300__ $$a160 - 174
000015400 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000015400 3367_ $$2DRIVER$$aarticle
000015400 440_0 $$04987$$aPlant Physiology$$v157$$x0032-0889$$y1
000015400 500__ $$aThis work was supported by Chemische Wetenschappen-ECHO (to T.L.D.), Netherlands Organisation for International Cooperation in Higher Education-PhD (to P.S.), the Biotechnological and Biological Sciences Research Council of the United Kingdom (grant no. BB/D006112/1 to L.F.P. and M.J.P.), Netherlands Organisation for Scientific Research Meervoud, and Utrecht University Cooperation Start-Up Fund Asia (to H.S.).
000015400 520__ $$aThe strong regulation of plant carbon allocation and growth by trehalose metabolism is important for our understanding of the mechanisms that determine growth and yield, with obvious applications in crop improvement. To gain further insight on the growth arrest by trehalose feeding, we first established that starch-deficient seedlings of the plastidic phosphoglucomutase1 mutant were similarly affected as the wild type on trehalose. Starch accumulation in the source cotyledons, therefore, did not cause starvation and consequent growth arrest in the growing zones. We then screened the FOX collection of Arabidopsis (Arabidopsis thaliana) expressing full-length cDNAs for seedling resistance to 100 mm trehalose. Three independent transgenic lines were identified with dominant segregation of the trehalose resistance trait that overexpress the bZIP11 (for basic region/leucine zipper motif) transcription factor. The resistance of these lines to trehalose could not be explained simply through enhanced trehalase activity or through inhibition of bZIP11 translation. Instead, trehalose-6-phosphate (T6P) accumulation was much increased in bZIP11-overexpressing lines, suggesting that these lines may be insensitive to the effects of T6P. T6P is known to inhibit the central stress-integrating kinase SnRK1 (KIN10) activity. We confirmed that this holds true in extracts from seedlings grown on trehalose, then showed that two independent transgenic lines overexpressing KIN10 were insensitive to trehalose. Moreover, the expression of marker genes known to be jointly controlled by SnRK1 activity and bZIP11 was consistent with low SnRK1 or bZIP11 activity in seedlings on trehalose. These results reveal an astonishing case of primary metabolite control over growth by way of the SnRK1 signaling pathway involving T6P, SnRK1, and bZIP11.
000015400 536__ $$0G:(DE-Juel1)FUEK407$$2G:(DE-HGF)$$aTerrestrische Umwelt$$cP24$$x0
000015400 588__ $$aDataset connected to Web of Science, Pubmed
000015400 650_2 $$2MeSH$$aArabidopsis: genetics
000015400 650_2 $$2MeSH$$aArabidopsis: metabolism
000015400 650_2 $$2MeSH$$aArabidopsis Proteins: genetics
000015400 650_2 $$2MeSH$$aArabidopsis Proteins: metabolism
000015400 650_2 $$2MeSH$$aBasic-Leucine Zipper Transcription Factors: genetics
000015400 650_2 $$2MeSH$$aDNA, Complementary
000015400 650_2 $$2MeSH$$aPlants, Genetically Modified
000015400 650_2 $$2MeSH$$aProtein Biosynthesis
000015400 650_2 $$2MeSH$$aProtein-Serine-Threonine Kinases: metabolism
000015400 650_2 $$2MeSH$$aSignal Transduction: drug effects
000015400 650_2 $$2MeSH$$aSugar Phosphates: metabolism
000015400 650_2 $$2MeSH$$aTrehalose: analogs & derivatives
000015400 650_2 $$2MeSH$$aTrehalose: metabolism
000015400 650_7 $$00$$2NLM Chemicals$$aATB2 protein, Arabidopsis
000015400 650_7 $$00$$2NLM Chemicals$$aArabidopsis Proteins
000015400 650_7 $$00$$2NLM Chemicals$$aBasic-Leucine Zipper Transcription Factors
000015400 650_7 $$00$$2NLM Chemicals$$aDNA, Complementary
000015400 650_7 $$00$$2NLM Chemicals$$aSugar Phosphates
000015400 650_7 $$04484-88-2$$2NLM Chemicals$$atrehalose-6-phosphate
000015400 650_7 $$099-20-7$$2NLM Chemicals$$aTrehalose
000015400 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aProtein-Serine-Threonine Kinases
000015400 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aSnRK1 protein, Arabidopsis
000015400 650_7 $$2WoSType$$aJ
000015400 7001_ $$0P:(DE-HGF)0$$aSedijani, P.$$b1
000015400 7001_ $$0P:(DE-HGF)0$$aKondou, Y.$$b2
000015400 7001_ $$0P:(DE-HGF)0$$aMatsui, M.$$b3
000015400 7001_ $$0P:(DE-HGF)0$$ade Jong, G.J.$$b4
000015400 7001_ $$0P:(DE-HGF)0$$aSomsen, G.W.$$b5
000015400 7001_ $$0P:(DE-Juel1)129420$$aWiese-Klinkenberg, A.$$b6$$uFZJ
000015400 7001_ $$0P:(DE-HGF)0$$aPrimavesi, L.F.$$b7
000015400 7001_ $$0P:(DE-HGF)0$$aPaul, M.J.$$b8
000015400 7001_ $$0P:(DE-HGF)0$$aSchluepmann, H.$$b9
000015400 773__ $$0PERI:(DE-600)2004346-6$$a10.1104/pp.111.180422$$gVol. 157, p. 160 - 174$$p160 - 174$$q157<160 - 174$$tPlant physiology$$v157$$x0032-0889$$y2011
000015400 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165867
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