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@ARTICLE{Jaeger:154401,
      author       = {Jaeger, Alexandra and Klum, S. and Weiss, D. G. and
                      Kriehuber, Ralf},
      title        = {{E}xpression profile of apoptosis related genes during
                      differentiation in the human neuronal progenitor cell line
                      {VM}197},
      journal      = {European journal of cell biology},
      volume       = {87},
      issn         = {0171-9335},
      address      = {München},
      publisher    = {Elsevier},
      reportid     = {FZJ-2014-03748},
      pages        = {S2-13},
      year         = {2008},
      abstract     = {The development of the human central nervous system is
                      accompanied by cell proliferation, differentiation and cell
                      death. The massive loss of neural cells during neurogenesis
                      suggests that apoptosis plays a critical role in human brain
                      development. To characterize apoptotic processes during
                      differentiation we analyzed the gene expression profiles of
                      proliferating versus differentiating ReNCell VM197 at six
                      different time points after induction of differentiation in
                      vitro. The expression levels of about 1,117 cDNA/ESTs
                      (expressed sequence tags) related to apoptosis pathways were
                      found to be changed at least 2-fold higher or lower in
                      differentiating cells than in proliferating cells.
                      Consistent with our previous Western/Immunoblotting studies,
                      we observed that pro-apoptotic proteins like Bax, Bid and
                      cytochrome c showed increased gene expression during the
                      first 6 h of differentiation and diminished expression
                      levels at later stages of differentiation. In contrast the
                      gene and protein expression levels of the anti-apoptotic
                      protein Bcl-2 was found to be increased 6 h and 12 h
                      respectively post-initiation of differentiation. We conclude
                      that both, pro-apoptotic and anti-apoptotic processes occur
                      during differentiation of VM197 cells and that Bcl-2 plays a
                      protective role against apoptosis in fully differentiated
                      neurons.},
      month         = {Mar},
      date          = {2008-03-12},
      organization  = {Annual Meeting of the German Society
                       for Cell Biology, Marburg (Germany), 12
                       Mar 2008 - 15 Mar 2008},
      cin          = {S-US},
      ddc          = {570},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF2-899)},
      pid          = {G:(DE-HGF)POF2-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.ejcb.2008.01.004},
      url          = {https://juser.fz-juelich.de/record/154401},
}