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@ARTICLE{Brzozowska:154584,
      author       = {Brzozowska, K. and Wojcik, A. and Kriehuber, R. and
                      Schmitz, Sabine},
      title        = {{C}omparison of {I}ndividual {R}adiosensitivity of {PBL}
                      from {P}rostate {C}ancer {P}atients and {H}ealthy {D}onors},
      journal      = {Radioprotection},
      volume       = {43},
      number       = {5},
      issn         = {1769-700X},
      address      = {Les Ulis},
      publisher    = {EDP Sciences},
      reportid     = {FZJ-2014-03878},
      pages        = {p.241},
      year         = {2008},
      abstract     = {Individual radiosensitivity is a biological feature
                      distributed heterogeneously withinthe population.
                      Approximately 10 $\%$ of people have an enhanced intrinsic
                      radiosensitvityand hence a higher risk for developing side
                      effects during radiotherapy. Theunderlying mechanisms remain
                      unclear. DNA repair deficiency and altered
                      apoptosischaracteristics are discussed to be markers for
                      radiosensitivity that can easilybe analysed in peripheral
                      blood lymphocytes (PBL). The aim of our study is tofind out
                      whether PBL from cancer patients with strong clinical side
                      effects underradiotherapy, as assessed clinically on the
                      basis of the RTOG/EORTC scale,show enhanced rates of double
                      strand breaks (dsb), decreased DNA repair capacityand
                      altered induction of apoptosis in vitro when compared to
                      lymphocytes frompatients without side effects and
                      age-matched healthy donors. Additionally, toinvestigate
                      whether the in vitro radiosensitivity of PBL is a marker of
                      prostatecancer predisposition the data of patients are
                      analysed versus the data of PBLcollected from healthy
                      donors. To achieve this goal blood samples are
                      collected,exposed to a dose of 1 Gy or 0.5 Gy and the
                      following biological endpoints are analysed:the initial
                      level of dsb and the repair kinetics (°-H2AX-Assay),
                      apoptosis(Annexin V-Assay) and the induction of
                      chromatid-type chromosomal aberrations(G2-Assay).
                      Preliminary results reveal that the maximum induction of
                      foci asmeasured by °-H2AX-Assay occurs 30 min after
                      irradiation. 24 h after irradiationthe amount of foci
                      declines to approximately control level. FACS data
                      confirmthese findings. First results derived from the
                      Annexin V-Assay show a significantincrease of early
                      apoptosis 24 h after irradiation compared to the controls.},
      organization  = {36th Annual Meeting of the European
                       Radiation Research Society, Tours
                       (France)},
      cin          = {S-US},
      ddc          = {530},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF2-899)},
      pid          = {G:(DE-HGF)POF2-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1051/radiopro:2008664},
      url          = {https://juser.fz-juelich.de/record/154584},
}