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@ARTICLE{Floeth:154899,
      author       = {Floeth, F. W. and Galldiks, N. and Eicker, S. and Stoffels,
                      G. and Herdmann, J. and Steiger, H. J. and Antoch, G. and
                      Rhee, S. and Langen, K. J.},
      title        = {{H}ypermetabolism in 18{F}-{FDG} {PET} {P}redicts
                      {F}avorable {O}utcome {F}ollowing {D}ecompressive {S}urgery
                      in {P}atients with {D}egenerative {C}ervical {M}yelopathy.},
      journal      = {Journal of nuclear medicine},
      volume       = {54},
      number       = {9},
      issn         = {0161-5505},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {FZJ-2014-04129},
      pages        = {1577 - 1583},
      year         = {2013},
      abstract     = {The aim of this study was to prospectively assess the
                      regional changes of glucose metabolism of the cervical
                      spinal cord in patients with degenerative cervical spine
                      stenosis and symptomatic cervical myelopathy after
                      decompressive surgery using 18F-FDG PET. Methods: Twenty
                      patients with symptomatic degenerative monosegmental
                      cervical stenosis with neuroradiologic signs of spinal cord
                      compression underwent decompressive surgery. The clinical
                      course using a functional status score (Japanese Orthopedic
                      Association [JOA] score), 18F-FDG uptake, and MR imaging
                      were assessed before and at follow-up 12 mo after surgery.
                      Pre- and postoperative changes of 18F-FDG PET were
                      correlated to the patients’ clinical outcome. Results: Ten
                      patients demonstrated preoperatively a focally increased
                      18F-FDG uptake at the level of the stenosis. At follow-up,
                      the uptake declined significantly (P = 0.008), and a
                      significant improvement of JOA scores (P < 0.001) could be
                      observed. The remaining 10 patients were characterized
                      preoperatively by an inconspicuous glucose uptake at the
                      level of cord compression in combination with a poststenotic
                      decrease of 18F-FDG uptake. At follow-up, both JOA scores
                      and 18F-FDG uptake changed insignificantly. Conclusion:
                      Focal glucose hypermetabolism at the level of cervical
                      spinal cord compression may predict an improved outcome
                      after surgical decompression. Thus, this finding on 18F-FDG
                      PET suggests a functional damage in a reversible phase of
                      cervical myelopathy.},
      cin          = {INM-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000324143400014},
      pubmed       = {pmid:23918736},
      doi          = {10.2967/jnumed.112.113183},
      url          = {https://juser.fz-juelich.de/record/154899},
}