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000015654 0247_ $$2DOI$$a10.1016/j.bbrc.2011.06.031
000015654 0247_ $$2WOS$$aWOS:000292797700037
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000015654 041__ $$aeng
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000015654 084__ $$2WoS$$aBiochemistry & Molecular Biology
000015654 084__ $$2WoS$$aBiophysics
000015654 1001_ $$0P:(DE-HGF)0$$aViale-Bouroncle, S.$$b0
000015654 245__ $$aSoft matrix supports osteogenic differentiation of human dental follicle cells
000015654 260__ $$aOrlando, Fla.$$bAcademic Press$$c2011
000015654 300__ $$a587 - 592
000015654 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000015654 440_0 $$0787$$aBiochemical and Biophysical Research Communications$$v410$$x0006-291X$$y3
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000015654 520__ $$aThe differentiation of stem cells can be directed by the grade of stiffness of the developed tissue cells. For example a rigid extracellular matrix supports the osteogenic differentiation in bone marrow derived mesenchymal stem cells (MSCs). However, less is known about the relation of extracellular matrix stiffness and cell differentiation of ectomesenchymal dental precursor cells. Our study examined for the first time the influence of the surface stiffness on the proliferation and osteogenic differentiation of human dental follicle cells (DFCs). Cell proliferation of DFCs was only slightly decreased on cell culture surfaces with a bone-like stiffness. The osteogenic differentiation in DFCs could only be initiated with a dexamethasone based differentiation medium after using varying stiffness. Here, the softest surface improved the induction of osteogenic differentiation in comparison to that with the highest stiffness. In conclusion, different to bone marrow derived MSCs, soft ECMs have a superior capacity to support the osteogenic differentiation of DFCs.
000015654 536__ $$0G:(DE-Juel1)FUEK505$$2G:(DE-HGF)$$aBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$cP45$$x0
000015654 588__ $$aDataset connected to Web of Science, Pubmed
000015654 650_2 $$2MeSH$$aCell Culture Techniques
000015654 650_2 $$2MeSH$$aCell Differentiation
000015654 650_2 $$2MeSH$$aCell Proliferation
000015654 650_2 $$2MeSH$$aCells, Cultured
000015654 650_2 $$2MeSH$$aCulture Media: pharmacology
000015654 650_2 $$2MeSH$$aDental Sac: cytology
000015654 650_2 $$2MeSH$$aDental Sac: drug effects
000015654 650_2 $$2MeSH$$aDexamethasone: pharmacology
000015654 650_2 $$2MeSH$$aHumans
000015654 650_2 $$2MeSH$$aMale
000015654 650_2 $$2MeSH$$aMesenchymal Stem Cells: cytology
000015654 650_2 $$2MeSH$$aMesenchymal Stem Cells: drug effects
000015654 650_2 $$2MeSH$$aOsteogenesis
000015654 650_2 $$2MeSH$$aSurface Properties
000015654 650_2 $$2MeSH$$aYoung Adult
000015654 650_7 $$00$$2NLM Chemicals$$aCulture Media
000015654 650_7 $$050-02-2$$2NLM Chemicals$$aDexamethasone
000015654 650_7 $$2WoSType$$aJ
000015654 65320 $$2Author$$aDental follicle cells
000015654 65320 $$2Author$$aPDMS
000015654 65320 $$2Author$$aDifferentiation
000015654 65320 $$2Author$$aProliferation
000015654 7001_ $$0P:(DE-HGF)0$$aVöllner, F.$$b1
000015654 7001_ $$0P:(DE-HGF)0$$aMöhl, C.$$b2
000015654 7001_ $$0P:(DE-Juel1)VDB26956$$aKüpper, K.$$b3$$uFZJ
000015654 7001_ $$0P:(DE-HGF)0$$aBrockhoff, G.$$b4
000015654 7001_ $$0P:(DE-Juel1)VDB99232$$aReichert, T.E.$$b5$$uFZJ
000015654 7001_ $$0P:(DE-Juel1)VDB99233$$aSchmalz, G.$$b6$$uFZJ
000015654 7001_ $$0P:(DE-Juel1)VDB99234$$aMorsczeck, C.$$b7$$uFZJ
000015654 773__ $$0PERI:(DE-600)1461396-7$$a10.1016/j.bbrc.2011.06.031$$gVol. 410, p. 587 - 592$$p587 - 592$$q410<587 - 592$$tBiochemical and biophysical research communications$$v410$$x0006-291X$$y2011
000015654 8567_ $$uhttp://dx.doi.org/10.1016/j.bbrc.2011.06.031
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000015654 9131_ $$0G:(DE-Juel1)FUEK505$$bSchlüsseltechnologien$$kP45$$lBiologische Informationsverarbeitung$$vBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$x0
000015654 9132_ $$0G:(DE-HGF)POF3-553$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lBioSoft  Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vPhysical Basis of Diseases$$x0
000015654 9141_ $$y2011
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