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@ARTICLE{VialeBouroncle:15654,
      author       = {Viale-Bouroncle, S. and Völlner, F. and Möhl, C. and
                      Küpper, K. and Brockhoff, G. and Reichert, T.E. and
                      Schmalz, G. and Morsczeck, C.},
      title        = {{S}oft matrix supports osteogenic differentiation of human
                      dental follicle cells},
      journal      = {Biochemical and biophysical research communications},
      volume       = {410},
      issn         = {0006-291X},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {PreJuSER-15654},
      pages        = {587 - 592},
      year         = {2011},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The differentiation of stem cells can be directed by the
                      grade of stiffness of the developed tissue cells. For
                      example a rigid extracellular matrix supports the osteogenic
                      differentiation in bone marrow derived mesenchymal stem
                      cells (MSCs). However, less is known about the relation of
                      extracellular matrix stiffness and cell differentiation of
                      ectomesenchymal dental precursor cells. Our study examined
                      for the first time the influence of the surface stiffness on
                      the proliferation and osteogenic differentiation of human
                      dental follicle cells (DFCs). Cell proliferation of DFCs was
                      only slightly decreased on cell culture surfaces with a
                      bone-like stiffness. The osteogenic differentiation in DFCs
                      could only be initiated with a dexamethasone based
                      differentiation medium after using varying stiffness. Here,
                      the softest surface improved the induction of osteogenic
                      differentiation in comparison to that with the highest
                      stiffness. In conclusion, different to bone marrow derived
                      MSCs, soft ECMs have a superior capacity to support the
                      osteogenic differentiation of DFCs.},
      keywords     = {Cell Culture Techniques / Cell Differentiation / Cell
                      Proliferation / Cells, Cultured / Culture Media:
                      pharmacology / Dental Sac: cytology / Dental Sac: drug
                      effects / Dexamethasone: pharmacology / Humans / Male /
                      Mesenchymal Stem Cells: cytology / Mesenchymal Stem Cells:
                      drug effects / Osteogenesis / Surface Properties / Young
                      Adult / Culture Media (NLM Chemicals) / Dexamethasone (NLM
                      Chemicals) / J (WoSType)},
      cin          = {ICS-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-7-20110106},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK505},
      shelfmark    = {Biochemistry $\&$ Molecular Biology / Biophysics},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21684253},
      UT           = {WOS:000292797700037},
      doi          = {10.1016/j.bbrc.2011.06.031},
      url          = {https://juser.fz-juelich.de/record/15654},
}