TY  - JOUR
AU  - Rosendahl, I.
AU  - Siemens, J.
AU  - Groeneweg, J.
AU  - Linzbach, E.
AU  - Laabs, V.
AU  - Herrmann, C.
AU  - Vereecken, H.
AU  - Amelung, W.
TI  - Dissipation and sequestration of the veterinary antibiotic sulfadiazine and its metabolites under field conditions
JO  - Environmental Science & Technology
VL  - 45
SN  - 0013-936X
CY  - Columbus, Ohio
PB  - American Chemical Society
M1  - PreJuSER-15723
SP  - 5216 - 5222
PY  - 2011
N1  - We thank Marisa Guttler for her great help in the lab, the team of the Frankenforst agricultural research station for providing their facilities for manure production, and Herbert Rutzel for supporting the field work. We furthermore thank Vetoquinol Biowet (Gorzow Wielkopolski, Poland) for preparing the SDZ injection solution, and our colleagues of the research unit FOR 566 for practical help during sampling campaigns and inspiring discussions of the results. This project was funded by the German Research Foundation (DFG) within the Research Unit FOR 566 "Veterinary medicines in soil: basic research for risk assessment" (AM 134/6-3).
AB  - Veterinary antibiotics introduced into the environment may change the composition and functioning of soil microbial communities and promote the spreading of antibiotic resistance. Actual risks depend on the antibiotic's persistence and (bio)accessibility, which may differ between laboratory and field conditions. We examined the dissipation and sequestration of sulfadiazine (SDZ) and its main metabolites in soil under field conditions and how it was influenced by temperature, soil moisture, plant roots, and soil aggregation compared to controlled laboratory experiments. A sequential extraction accounted for easily extractable (CaCl₂-extractable) and sequestered (microwave-extractable, residual) SDZ fractions. Dissipation from both fractions was largely temperature-dependent and could be well predicted from laboratory data recorded at different temperatures. Soil moisture additionally seemed to control sequestration, being accelerated in dry soil. Sequestration, as indicated by increasing apparent distribution coefficients and decreasing rates of kinetic release into CaCl₂, governed the antibiotic's long-term fate in soil. Besides, we observed spatial gradients of antibiotic concentrations across soil aggregates and in the vicinity of roots. The former were short-lived and equilibrated due to aggregate reorganization, while dissipation of the easily extractable fraction was accelerated near roots throughout the growth period. There was little if any impact of the plants on residual SDZ concentrations.
KW  - Anti-Bacterial Agents: isolation & purification
KW  - Biodegradation, Environmental
KW  - Environmental Monitoring
KW  - Environmental Remediation: methods
KW  - Rhizosphere
KW  - Soil: chemistry
KW  - Sulfadiazine: analogs & derivatives
KW  - Sulfadiazine: isolation & purification
KW  - Veterinary Drugs: analogs & derivatives
KW  - Veterinary Drugs: isolation & purification
KW  - Zea mays: metabolism
KW  - Anti-Bacterial Agents (NLM Chemicals)
KW  - Soil (NLM Chemicals)
KW  - Veterinary Drugs (NLM Chemicals)
KW  - Sulfadiazine (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21595431
UR  - <Go to ISI:>//WOS:000291422200024
DO  - DOI:10.1021/es200326t
UR  - https://juser.fz-juelich.de/record/15723
ER  -