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000015775 0247_ $$2DOI$$a10.1016/j.neuroimage.2011.06.027
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000015775 041__ $$aeng
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000015775 084__ $$2WoS$$aNeurosciences
000015775 084__ $$2WoS$$aNeuroimaging
000015775 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000015775 1001_ $$0P:(DE-Juel1)VDB53458$$aCaspers, S.$$b0$$uFZJ
000015775 245__ $$aProbabilistic fibre tract analysis of cytoarchtitectonically defined human inferior parietal lobule areas reveals similatrities to macaques
000015775 260__ $$aOrlando, Fla.$$bAcademic Press$$c2011
000015775 300__ $$a362 - 380
000015775 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000015775 3367_ $$2BibTeX$$aARTICLE
000015775 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000015775 3367_ $$2DRIVER$$aarticle
000015775 440_0 $$04545$$aNeuroImage$$v58$$x1053-8119$$y2
000015775 500__ $$aThis Human Brain Project/Neuroinformatics Research was funded by the National Institute of Biomedical Imaging and Bioengeneering, the National Institute of Neurological Disorders and Stroke and the National Institute of Mental Health (KZ). Further funding was granted by the Human Brain Project (R01-MH074457-01A1; SBE), the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model; KZ, SBE), and the Helmholtz Alliance for Mental Health in an Aging Society (HelMA; KZ).
000015775 520__ $$aThe human inferior parietal lobule (IPL) is a multimodal brain region, subdivided in several cytoarchitectonic areas which are involved in neural networks related to spatial attention, language, and higher motor processing. Tracer studies in macaques revealed differential connectivity patterns of IPL areas as the respective structural basis. Evidence for comparable differential fibre tracts of human IPL is lacking. Here, anatomical connectivity of five cytoarchitectonic human IPL areas to 64 cortical targets was investigated using probabilistic tractography. Connection likelihood was assessed by evaluating the number of traces between seed and target against the distribution of traces from that seed to voxels in the same distance as the target. The main fibre tract pattern shifted gradually from rostral to caudal IPL: Rostral areas were predominantly connected to somatosensory and superior parietal areas while caudal areas more strongly connected with auditory, anterior temporal and higher visual cortices. All IPL areas were strongly connected with inferior frontal, insular and posterior temporal areas. These results showed striking similarities with connectivity patterns in macaques, providing further evidence for possible homologies between these two species. This shift in fibre tract pattern supports a differential functional involvement of rostral (higher motor functions) and caudal IPL (spatial attention), with probable overlapping language involvement. The differential functional involvement of IPL areas was further supported by hemispheric asymmetries of connection patterns which showed left-right differences especially with regard to connections to sensorimotor, inferior frontal and temporal areas.
000015775 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000015775 536__ $$0G:(DE-HGF)POF2-89573$$a89573 - Neuroimaging (POF2-89573)$$cPOF2-89573$$fPOF II T$$x1
000015775 588__ $$aDataset connected to Web of Science, Pubmed
000015775 65320 $$2Author$$aDiffusion tensor imaging
000015775 65320 $$2Author$$aDTI
000015775 65320 $$2Author$$aProbabilistic tractography
000015775 65320 $$2Author$$aInferior parietal
000015775 65320 $$2Author$$aFibre tract
000015775 65320 $$2Author$$aCytoarchitecture
000015775 650_2 $$2MeSH$$aAdult
000015775 650_2 $$2MeSH$$aAnimals
000015775 650_2 $$2MeSH$$aCerebral Cortex: anatomy & histology
000015775 650_2 $$2MeSH$$aCerebral Cortex: physiology
000015775 650_2 $$2MeSH$$aDiffusion Tensor Imaging: methods
000015775 650_2 $$2MeSH$$aFemale
000015775 650_2 $$2MeSH$$aHumans
000015775 650_2 $$2MeSH$$aImage Processing, Computer-Assisted
000015775 650_2 $$2MeSH$$aMacaca
000015775 650_2 $$2MeSH$$aMale
000015775 650_2 $$2MeSH$$aModels, Statistical
000015775 650_2 $$2MeSH$$aNerve Fibers: physiology
000015775 650_2 $$2MeSH$$aNeural Pathways: anatomy & histology
000015775 650_2 $$2MeSH$$aNeural Pathways: physiology
000015775 650_2 $$2MeSH$$aParietal Lobe: anatomy & histology
000015775 650_2 $$2MeSH$$aParietal Lobe: physiology
000015775 650_2 $$2MeSH$$aSpecies Specificity
000015775 650_2 $$2MeSH$$aYoung Adult
000015775 650_7 $$2WoSType$$aJ
000015775 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S.B.$$b1$$uFZJ
000015775 7001_ $$0P:(DE-HGF)0$$aRick, T.$$b2
000015775 7001_ $$0P:(DE-HGF)0$$avon Kapri, A.$$b3
000015775 7001_ $$0P:(DE-HGF)0$$aKuhlen, T.$$b4
000015775 7001_ $$0P:(DE-Juel1)VDB34896$$aHuang, R.$$b5$$uFZJ
000015775 7001_ $$0P:(DE-Juel1)131794$$aShah, N.J.$$b6$$uFZJ
000015775 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b7$$uFZJ
000015775 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2011.06.027$$gVol. 58, p. 362 - 380$$p362 - 380$$q58<362 - 380$$tNeuroImage$$v58$$x1053-8119$$y2011
000015775 8567_ $$uhttp://dx.doi.org/10.1016/j.neuroimage.2011.06.027
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000015775 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000015775 9141_ $$y2011
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