Journal Article

PreJuSER-15775

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Probabilistic fibre tract analysis of cytoarchtitectonically defined human inferior parietal lobule areas reveals similatrities to macaques

Caspers, S.FZJ* ; Eickhoff, S. B.FZJ* ; Rick, T. ; von Kapri, A. ; Kuhlen, T. ; Huang, R.FZJ* ; Shah, N. J.FZJ* ; Zilles, K.FZJ*

2011
Academic Press Orlando, Fla.

This record in other databases:      

Please use a persistent id in citations: doi:10.1016/j.neuroimage.2011.06.027

Abstract: The human inferior parietal lobule (IPL) is a multimodal brain region, subdivided in several cytoarchitectonic areas which are involved in neural networks related to spatial attention, language, and higher motor processing. Tracer studies in macaques revealed differential connectivity patterns of IPL areas as the respective structural basis. Evidence for comparable differential fibre tracts of human IPL is lacking. Here, anatomical connectivity of five cytoarchitectonic human IPL areas to 64 cortical targets was investigated using probabilistic tractography. Connection likelihood was assessed by evaluating the number of traces between seed and target against the distribution of traces from that seed to voxels in the same distance as the target. The main fibre tract pattern shifted gradually from rostral to caudal IPL: Rostral areas were predominantly connected to somatosensory and superior parietal areas while caudal areas more strongly connected with auditory, anterior temporal and higher visual cortices. All IPL areas were strongly connected with inferior frontal, insular and posterior temporal areas. These results showed striking similarities with connectivity patterns in macaques, providing further evidence for possible homologies between these two species. This shift in fibre tract pattern supports a differential functional involvement of rostral (higher motor functions) and caudal IPL (spatial attention), with probable overlapping language involvement. The differential functional involvement of IPL areas was further supported by hemispheric asymmetries of connection patterns which showed left-right differences especially with regard to connections to sensorimotor, inferior frontal and temporal areas.

Keyword(s): Adult (MeSH) ; Animals (MeSH) ; Cerebral Cortex: anatomy & histology (MeSH) ; Cerebral Cortex: physiology (MeSH) ; Diffusion Tensor Imaging: methods (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Image Processing, Computer-Assisted (MeSH) ; Macaca (MeSH) ; Male (MeSH) ; Models, Statistical (MeSH) ; Nerve Fibers: physiology (MeSH) ; Neural Pathways: anatomy & histology (MeSH) ; Neural Pathways: physiology (MeSH) ; Parietal Lobe: anatomy & histology (MeSH) ; Parietal Lobe: physiology (MeSH) ; Species Specificity (MeSH) ; Young Adult (MeSH) ; J ; Diffusion tensor imaging (auto) ; DTI (auto) ; Probabilistic tractography (auto) ; Inferior parietal (auto) ; Fibre tract (auto) ; Cytoarchitecture (auto)

Note: This Human Brain Project/Neuroinformatics Research was funded by the National Institute of Biomedical Imaging and Bioengeneering, the National Institute of Neurological Disorders and Stroke and the National Institute of Mental Health (KZ). Further funding was granted by the Human Brain Project (R01-MH074457-01A1; SBE), the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model; KZ, SBE), and the Helmholtz Alliance for Mental Health in an Aging Society (HelMA; KZ).

---

Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)
2. Physik der Medizinischen Bildgebung (INM-4)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89573 - Neuroimaging (POF2-89573) (POF2-89573)

Appears in the scientific report 2011

---