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000015797 0247_ $$2DOI$$a10.1002/eji.200939234
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000015797 084__ $$2WoS$$aImmunology
000015797 1001_ $$0P:(DE-HGF)0$$aKramer, B.$$b0
000015797 245__ $$aRegulation of NK Cell Trafficking by CD81
000015797 260__ $$aWeinheim$$bWiley-VCH$$c2009
000015797 300__ $$a3447 - 3458
000015797 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000015797 440_0 $$024221$$aEuropean Journal of Immunology$$v39$$y12
000015797 500__ $$aThis work was supported by a grant from BMBF (German Ministry for Science and Education) (01KI0791). We thank Dirk Stabenow from the Institute of Molecular Medicine and Experimental Immunology, University of Bonn, for his support performing calcium influx.
000015797 520__ $$aNK cells, a heterogeneous sub-population of lymphocytes, are critically involved in the regulation of both innate and adaptive immune responses in humans. Besides their participation in the control of tumors and viral infections, they also regulate inflammatory processes, mediating both beneficial and detrimental effects. To effectively fulfil their role in immune surveillance, proper trafficking of NK cells is essential. However, the mechanisms and factors governing NK cell recruitment are only poorly dissected. Here, we describe the functional role of tetraspanins, a family of evolutionary conserved cell-surface proteins, in modulating migration and transmigration of human NK cells. We demonstrate expression of various tetraspanins on NK cells. Furthermore, we show that stimulation of the NK cell-expressed tetraspanin CD81 induces phosphorylation of ezrin/radixin/moesin proteins and leads to NK cell polarization thereby facilitating NK cell migration toward various chemokines/cytokines. Finally, we provide evidence for a role of CD81 in promoting adhesion of NK cells to components of the extracellular matrix, a prerequisite for extravasation of lymphocytes in inflamed tissues. Thus, our data suggest that the tetraspanin CD81 is importantly involved in the regulation of NK cell recruitment.
000015797 536__ $$0G:(DE-Juel1)FUEK505$$2G:(DE-HGF)$$aBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$cP45$$x0
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000015797 65320 $$2Author$$aAdhesion
000015797 65320 $$2Author$$aCell migration
000015797 65320 $$2Author$$aCell trafficking
000015797 65320 $$2Author$$aChemokines
000015797 65320 $$2Author$$aNK cells
000015797 650_2 $$2MeSH$$aAntigens, CD: metabolism
000015797 650_2 $$2MeSH$$aAntigens, CD63
000015797 650_2 $$2MeSH$$aAntigens, CD81
000015797 650_2 $$2MeSH$$aBlotting, Western
000015797 650_2 $$2MeSH$$aCell Adhesion
000015797 650_2 $$2MeSH$$aCell Movement
000015797 650_2 $$2MeSH$$aCell Polarity
000015797 650_2 $$2MeSH$$aChemokine CCL5: metabolism
000015797 650_2 $$2MeSH$$aChemokine CCL5: pharmacology
000015797 650_2 $$2MeSH$$aChemotaxis: drug effects
000015797 650_2 $$2MeSH$$aCytoskeletal Proteins: metabolism
000015797 650_2 $$2MeSH$$aFlow Cytometry
000015797 650_2 $$2MeSH$$aHumans
000015797 650_2 $$2MeSH$$aKiller Cells, Natural: cytology
000015797 650_2 $$2MeSH$$aKiller Cells, Natural: metabolism
000015797 650_2 $$2MeSH$$aMembrane Proteins: metabolism
000015797 650_2 $$2MeSH$$aMicrofilament Proteins: metabolism
000015797 650_2 $$2MeSH$$aPhosphorylation
000015797 650_2 $$2MeSH$$aPlatelet Membrane Glycoproteins: metabolism
000015797 650_2 $$2MeSH$$aProtein Binding
000015797 650_2 $$2MeSH$$aProtein Kinase C: metabolism
000015797 650_2 $$2MeSH$$arho-Associated Kinases: metabolism
000015797 650_7 $$00$$2NLM Chemicals$$aAntigens, CD
000015797 650_7 $$00$$2NLM Chemicals$$aAntigens, CD63
000015797 650_7 $$00$$2NLM Chemicals$$aAntigens, CD81
000015797 650_7 $$00$$2NLM Chemicals$$aCD63 protein, human
000015797 650_7 $$00$$2NLM Chemicals$$aCD81 protein, human
000015797 650_7 $$00$$2NLM Chemicals$$aChemokine CCL5
000015797 650_7 $$00$$2NLM Chemicals$$aCytoskeletal Proteins
000015797 650_7 $$00$$2NLM Chemicals$$aMembrane Proteins
000015797 650_7 $$00$$2NLM Chemicals$$aMicrofilament Proteins
000015797 650_7 $$00$$2NLM Chemicals$$aPlatelet Membrane Glycoproteins
000015797 650_7 $$00$$2NLM Chemicals$$aezrin
000015797 650_7 $$0144131-77-1$$2NLM Chemicals$$amoesin
000015797 650_7 $$0144517-21-5$$2NLM Chemicals$$aradixin
000015797 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$arho-Associated Kinases
000015797 650_7 $$0EC 2.7.11.13$$2NLM Chemicals$$aProtein Kinase C
000015797 650_7 $$2WoSType$$aJ
000015797 7001_ $$0P:(DE-HGF)0$$aSchulte, D.$$b1
000015797 7001_ $$0P:(DE-HGF)0$$aKorner, C.$$b2
000015797 7001_ $$0P:(DE-HGF)0$$aZwank, C.$$b3
000015797 7001_ $$0P:(DE-HGF)0$$aHartmann, A.$$b4
000015797 7001_ $$0P:(DE-HGF)0$$aMichalk, M.$$b5
000015797 7001_ $$0P:(DE-HGF)0$$aSohne, J.$$b6
000015797 7001_ $$0P:(DE-HGF)0$$aLanghans, B.$$b7
000015797 7001_ $$0P:(DE-HGF)0$$aNischalke, H.D.$$b8
000015797 7001_ $$0P:(DE-HGF)0$$aCoenen, M.$$b9
000015797 7001_ $$0P:(DE-Juel1)VDB71075$$aMöhl, C.$$b10$$uFZJ
000015797 7001_ $$0P:(DE-HGF)0$$aVogt, A.$$b11
000015797 7001_ $$0P:(DE-HGF)0$$aHennenberg, M.$$b12
000015797 7001_ $$0P:(DE-HGF)0$$aSauerbruch, T.$$b13
000015797 7001_ $$0P:(DE-HGF)0$$aSpengler, U.$$b14
000015797 7001_ $$0P:(DE-HGF)0$$aNattermann, J.$$b15
000015797 773__ $$0PERI:(DE-600)1491907-2$$a10.1002/eji.200939234$$gVol. 39, p. 3447 - 3458$$p3447 - 3458$$q39<3447 - 3458$$tEuropean journal of immunology$$v39$$x0014-2980$$y2009
000015797 8567_ $$uhttp://dx.doi.org/10.1002/eji.200939234
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