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| 001 | 15797 | ||
| 005 | 20200402210030.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:19830727 |
| 024 | 7 | _ | |2 DOI |a 10.1002/eji.200939234 |
| 024 | 7 | _ | |2 WOS |a WOS:000272928300021 |
| 037 | _ | _ | |a PreJuSER-15797 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 084 | _ | _ | |2 WoS |a Immunology |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Kramer, B. |b 0 |
| 245 | _ | _ | |a Regulation of NK Cell Trafficking by CD81 |
| 260 | _ | _ | |a Weinheim |b Wiley-VCH |c 2009 |
| 300 | _ | _ | |a 3447 - 3458 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |0 24221 |a European Journal of Immunology |v 39 |y 12 |
| 500 | _ | _ | |a This work was supported by a grant from BMBF (German Ministry for Science and Education) (01KI0791). We thank Dirk Stabenow from the Institute of Molecular Medicine and Experimental Immunology, University of Bonn, for his support performing calcium influx. |
| 520 | _ | _ | |a NK cells, a heterogeneous sub-population of lymphocytes, are critically involved in the regulation of both innate and adaptive immune responses in humans. Besides their participation in the control of tumors and viral infections, they also regulate inflammatory processes, mediating both beneficial and detrimental effects. To effectively fulfil their role in immune surveillance, proper trafficking of NK cells is essential. However, the mechanisms and factors governing NK cell recruitment are only poorly dissected. Here, we describe the functional role of tetraspanins, a family of evolutionary conserved cell-surface proteins, in modulating migration and transmigration of human NK cells. We demonstrate expression of various tetraspanins on NK cells. Furthermore, we show that stimulation of the NK cell-expressed tetraspanin CD81 induces phosphorylation of ezrin/radixin/moesin proteins and leads to NK cell polarization thereby facilitating NK cell migration toward various chemokines/cytokines. Finally, we provide evidence for a role of CD81 in promoting adhesion of NK cells to components of the extracellular matrix, a prerequisite for extravasation of lymphocytes in inflamed tissues. Thus, our data suggest that the tetraspanin CD81 is importantly involved in the regulation of NK cell recruitment. |
| 536 | _ | _ | |0 G:(DE-Juel1)FUEK505 |2 G:(DE-HGF) |a BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung |c P45 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Antigens, CD: metabolism |
| 650 | _ | 2 | |2 MeSH |a Antigens, CD63 |
| 650 | _ | 2 | |2 MeSH |a Antigens, CD81 |
| 650 | _ | 2 | |2 MeSH |a Blotting, Western |
| 650 | _ | 2 | |2 MeSH |a Cell Adhesion |
| 650 | _ | 2 | |2 MeSH |a Cell Movement |
| 650 | _ | 2 | |2 MeSH |a Cell Polarity |
| 650 | _ | 2 | |2 MeSH |a Chemokine CCL5: metabolism |
| 650 | _ | 2 | |2 MeSH |a Chemokine CCL5: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Chemotaxis: drug effects |
| 650 | _ | 2 | |2 MeSH |a Cytoskeletal Proteins: metabolism |
| 650 | _ | 2 | |2 MeSH |a Flow Cytometry |
| 650 | _ | 2 | |2 MeSH |a Humans |
| 650 | _ | 2 | |2 MeSH |a Killer Cells, Natural: cytology |
| 650 | _ | 2 | |2 MeSH |a Killer Cells, Natural: metabolism |
| 650 | _ | 2 | |2 MeSH |a Membrane Proteins: metabolism |
| 650 | _ | 2 | |2 MeSH |a Microfilament Proteins: metabolism |
| 650 | _ | 2 | |2 MeSH |a Phosphorylation |
| 650 | _ | 2 | |2 MeSH |a Platelet Membrane Glycoproteins: metabolism |
| 650 | _ | 2 | |2 MeSH |a Protein Binding |
| 650 | _ | 2 | |2 MeSH |a Protein Kinase C: metabolism |
| 650 | _ | 2 | |2 MeSH |a rho-Associated Kinases: metabolism |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Antigens, CD |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Antigens, CD63 |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Antigens, CD81 |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a CD63 protein, human |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a CD81 protein, human |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Chemokine CCL5 |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Cytoskeletal Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Membrane Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Microfilament Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Platelet Membrane Glycoproteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a ezrin |
| 650 | _ | 7 | |0 144131-77-1 |2 NLM Chemicals |a moesin |
| 650 | _ | 7 | |0 144517-21-5 |2 NLM Chemicals |a radixin |
| 650 | _ | 7 | |0 EC 2.7.11.1 |2 NLM Chemicals |a rho-Associated Kinases |
| 650 | _ | 7 | |0 EC 2.7.11.13 |2 NLM Chemicals |a Protein Kinase C |
| 650 | _ | 7 | |2 WoSType |a J |
| 653 | 2 | 0 | |2 Author |a Adhesion |
| 653 | 2 | 0 | |2 Author |a Cell migration |
| 653 | 2 | 0 | |2 Author |a Cell trafficking |
| 653 | 2 | 0 | |2 Author |a Chemokines |
| 653 | 2 | 0 | |2 Author |a NK cells |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Schulte, D. |b 1 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Korner, C. |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Zwank, C. |b 3 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Hartmann, A. |b 4 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Michalk, M. |b 5 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Sohne, J. |b 6 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Langhans, B. |b 7 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Nischalke, H.D. |b 8 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Coenen, M. |b 9 |
| 700 | 1 | _ | |0 P:(DE-Juel1)VDB71075 |a Möhl, C. |b 10 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Vogt, A. |b 11 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Hennenberg, M. |b 12 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Sauerbruch, T. |b 13 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Spengler, U. |b 14 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Nattermann, J. |b 15 |
| 773 | _ | _ | |0 PERI:(DE-600)1491907-2 |a 10.1002/eji.200939234 |g Vol. 39, p. 3447 - 3458 |p 3447 - 3458 |q 39<3447 - 3458 |t European journal of immunology |v 39 |x 0014-2980 |y 2009 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1002/eji.200939234 |
| 909 | C | O | |o oai:juser.fz-juelich.de:15797 |p VDB |
| 913 | 1 | _ | |0 G:(DE-Juel1)FUEK505 |a DE-HGF |b Schlüsseltechnologien |k P45 |l Biologische Informationsverarbeitung |v BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung |x 0 |
| 914 | 1 | _ | |a Nachtrag |y 2009 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0040 |2 StatID |a Peer review unknown |
| 915 | _ | _ | |0 StatID:(DE-HGF)0100 |2 StatID |a JCR |
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| 915 | _ | _ | |0 StatID:(DE-HGF)0150 |2 StatID |a DBCoverage |b Web of Science Core Collection |
| 915 | _ | _ | |0 StatID:(DE-HGF)0199 |2 StatID |a DBCoverage |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |0 StatID:(DE-HGF)0300 |2 StatID |a DBCoverage |b Medline |
| 920 | 1 | _ | |0 I:(DE-Juel1)ICS-7-20110106 |g ICS |k ICS-7 |l Biomechanik |x 0 |
| 970 | _ | _ | |a VDB:(DE-Juel1)129111 |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a ConvertedRecord |
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| 980 | _ | _ | |a UNRESTRICTED |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-2-20200312 |
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